Structure of PDB 6b0p Chain A Binding Site BS03

Receptor Information

>6b0p Chain A (length=118) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

HMRPFMCAYPGCNKRYFKLSHLQMHSRKHTGEKPYQCDFKDCERRFSRSD
QLKRHQRRHTGVKPFQCKTCQRKFSRSDHLKTHTRTHTGEKPFSCRWPSC
QKKFARSDELVRHHNMHQ

Ligand information

InChI=1S/Zn/q+2

PTFCDOFLOPIGGS-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.341	[Zn++]
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Zn+2]

Formula

Zn

Name

ZINC ION

PDB chain

6b0p Chain A Residue 501 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	6b0p Role for first zinc finger of WT1 in DNA sequence specificity: Denys-Drash syndrome-associated WT1 mutant in ZF1 enhances affinity for a subset of WT1 binding sites.
Resolution	2.077 Å
Binding residue (original residue number in PDB)	C325 C330 H343 H347
Binding residue (residue number reindexed from 1)	C7 C12 H25 H29
Annotation score	4

Enzymatic activity

Enzyme Commision number

External links

PDB	RCSB:6b0p, PDBe:6b0p, PDBj:6b0p
PDBsum	6b0p
PubMed	29294058
UniProt	P19544\|WT1_HUMAN Wilms tumor protein (Gene Name=WT1)

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