Structure of PDB 6alo Chain A Binding Site BS03

Receptor Information
>6alo Chain A (length=337) Species: 1960 (Streptomyces vinaceus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RPWSEFRLTPAEAAAAAALAARCAQRYDETDGPEFLLDAPVIAHELPRRL
RTFMARARLDAWPHALVVRGNPVDDAALGSTPVHWRTARTPGSRPLSFLL
MLYAGLLGDVFGWATQQDGRVVTDVLPIKGGEHTLVSSSSRQELGWHTED
AFSPYRADYVGLLSLRNPDGVATTLAGVPLDDLDERTLDVLFQERFLIRP
DDSHLQVNNSTAQQGRVEFEGIAQAADRPEPVAILTGHRAAPHLRVDGDF
SAPAEGDEEAAAALGTLRKLIDASLYELVLDQGDVAFIDNRRAVHGRRAF
QPRYDGRDRWLKRINITRDLHRSRKAWAGDSRVLGQR
Ligand information
Ligand IDOKG
InChIInChI=1S/C4H6O5/c5-3(6)1-2-4(7)9-8/h8H,1-2H2,(H,5,6)/p-1
InChIKeyWBOQHFMXKCEWSQ-UHFFFAOYSA-M
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.6C(CC(=O)O[O-])C(=O)O
ACDLabs 12.01
CACTVS 3.385		OC(=O)CCC(=O)O[O-]
FormulaC4 H5 O5
Name4-peroxy-4-oxobutanoic acid
ChEMBL
DrugBank
ZINC
PDB chain6alo Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6alo Visualizing the Reaction Cycle in an Iron(II)- and 2-(Oxo)-glutarate-Dependent Hydroxylase.
Resolution1.79 Å
Binding residue
(original residue number in PDB)		L165 H168 E170 H316 R318 R330 L332 R334
Binding residue
(residue number reindexed from 1)		L144 H147 E149 H295 R297 R309 L311 R313
Annotation score2
Enzymatic activity
Enzyme Commision number 1.14.11.41: L-arginine hydroxylase.
Gene Ontology
Molecular Function
GO:0005506 iron ion binding
GO:0016491 oxidoreductase activity
GO:0016706 2-oxoglutarate-dependent dioxygenase activity
GO:0046872 metal ion binding
GO:0102525 2-oxoglutarate, L-arginine oxygenase (succinate-forming) activity
Biological Process
GO:0017000 antibiotic biosynthetic process
Cellular Component
GO:0016020 membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6alo, PDBe:6alo, PDBj:6alo
PDBsum6alo
PubMed28823155
UniProtQ6WZB0|ARGHX_STRVI Alpha-ketoglutarate-dependent L-arginine hydroxylase (Gene Name=vioC)

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