Structure of PDB 6alb Chain A Binding Site BS03

Receptor Information
>6alb Chain A (length=212) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SRKKIFKPEELRQALMPTLEALYRQDPESLPFRQPVDPQLLGIPDYFDIV
KNPMDLSTIKRKLDTGQYQEPWQYVDDVWLMFNNAWLYNRKTSRVYKFCS
KLAEVFEQEIDPVMQSLGYCCGRKYEFSPQTLCCYLCTIPRDAAYYSYQN
RYHFCEKCFDPSQPQTTEKKKNDTLDPEPFVDCKECGRKMHQICVLHYDI
IWPSGFVCDNCL
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain6alb Chain A Residue 1403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6alb Design and Synthesis of A Biaryl Series As Inhibitors for the Bromodomains of CBP/P300
Resolution2.053 Å
Binding residue
(original residue number in PDB)		C1213 C1219
Binding residue
(residue number reindexed from 1)		C134 C137
Annotation score1
Enzymatic activity
Enzyme Commision number 2.3.1.-
2.3.1.48: histone acetyltransferase.
Gene Ontology
Molecular Function
GO:0004402 histone acetyltransferase activity
Biological Process
GO:0006355 regulation of DNA-templated transcription

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Molecular Function
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Biological Process
External links
PDB RCSB:6alb, PDBe:6alb, PDBj:6alb
PDBsum6alb
PubMed
UniProtQ92793|CBP_HUMAN CREB-binding protein (Gene Name=CREBBP)

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