Structure of PDB 6ak7 Chain A Binding Site BS03

Receptor Information
>6ak7 Chain A (length=257) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ISLAKVGCASQIGKRKENEDRFDFAQLTDEVLYFAVYDGHGGPAAADFCH
THMEKCIMDLLPKEANLETLLTLAFLEIDKAFSSHARLSADATLLTSGTT
ATVALLRDGIELVVASVGDSRAILCRKGKPMKLTIDHTPERADEKERIKK
CGGFVAWNQPHVNGRLAMTRSIGDLDLKTSGVIAEPETKRIKLHHADDSF
LVLTTDGINFMVNSQEICDFVNQCHDPNEAAHAVTEQAIQYGTEDNSTAV
VVPFGAW
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain6ak7 Chain A Residue 506 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6ak7 Structure of PPM1K-N94K mutant at 2.61 Angstroms resolution
Resolution2.605 Å
Binding residue
(original residue number in PDB)		D112 E143
Binding residue
(residue number reindexed from 1)		D23 E54
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.16: protein-serine/threonine phosphatase.
3.1.3.52: [3-methyl-2-oxobutanoate dehydrogenase (2-methylpropanoyl-transferring)]- phosphatase.
Gene Ontology
Molecular Function
GO:0004722 protein serine/threonine phosphatase activity
GO:0043169 cation binding
Biological Process
GO:0006470 protein dephosphorylation

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Molecular Function
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Biological Process
External links
PDB RCSB:6ak7, PDBe:6ak7, PDBj:6ak7
PDBsum6ak7
PubMed
UniProtQ8N3J5|PPM1K_HUMAN Protein phosphatase Mn(2+)-dependent 1K (Gene Name=PPM1K)

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