Structure of PDB 6a9v Chain A Binding Site BS03

Receptor Information
>6a9v Chain A (length=393) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GELTPGISALEYYERRIRLAETLPPKSCVILAGNDIFQQENDLFYLSGWN
EPNSVMILEKPTDSLSDTIFHMLVPPGVQEIFNADESASINDLSKYLPKI
INRNDFIYFDMLSSSNFKHIKSLLTIKPISKRIAEFRKIKSPQELRIMRR
AGQISGRSFNQAFAKRFRNERTLDSFLHYKFISGGCDKDAYIPVVATGSN
SLCIHYTRNDDVMFDDEMVLVDAAGSLGGYCADISRTWPNSGKFTDAQRD
LYEAVLNVQRDCIKLCKASNNYSLHDIHEKSITLMKQELKNLGIDKVSGW
NVEKLYPHYIGHNLGLDVHDVPKVSRYEPLKVGQVITIEPGLYIPNEESF
PSYFRNVGIRIEDDIAIGEDTYTNLTVEAVKEIDDLENVMQNG
Ligand information
Ligand IDGLY
InChIInChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(=O)O)N
CACTVS 3.341NCC(O)=O
ACDLabs 10.04O=C(O)CN
FormulaC2 H5 N O2
NameGLYCINE
ChEMBLCHEMBL773
DrugBankDB00145
ZINCZINC000004658552
PDB chain6a9v Chain A Residue 604 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB6a9v Crystal structures and biochemical analyses of intermediate cleavage peptidase: role of dynamics in enzymatic function.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		Y296 D327 D338 H417 H424 E444
Binding residue
(residue number reindexed from 1)		Y191 D222 D233 H312 H319 E339
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.26: intermediate cleaving peptidase 55.
Gene Ontology
Molecular Function
GO:0004177 aminopeptidase activity
GO:0008237 metallopeptidase activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070006 metalloaminopeptidase activity
Biological Process
GO:0006508 proteolysis
GO:0016485 protein processing
GO:0050821 protein stabilization
Cellular Component
GO:0005634 nucleus
GO:0005739 mitochondrion
GO:0005743 mitochondrial inner membrane

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:6a9v, PDBe:6a9v, PDBj:6a9v
PDBsum6a9v
PubMed30582634
UniProtP40051|ICP55_YEAST Intermediate cleaving peptidase 55 (Gene Name=ICP55)

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