Structure of PDB 6a9t Chain A Binding Site BS03

Receptor Information
>6a9t Chain A (length=417) Species: 559292 (Saccharomyces cerevisiae S288C) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SGELTPGISALEYYERRIRLAETLPPKSCVILAGNDIQFFYPFQQENDLF
YLSGWNEPNSVMILEKPTDSLSDTIFHMLVPPKDAFAEKWEFRSGVYGVQ
EIFNADESASINDLSKYLPKIINRNEFIYFDMLSSSSNFKHIKSLLDTIK
PISKRIAEFRKIKSPQELRIMRRAGQISGRSFNQAFAKRFRNERTLDSFL
HYKFISGGCDKDAYIPVVATGSNSLCIHYTRNDDVMFDDEMVLVDAAGSL
GGYCADISRTWPNSGKFTDAQRDLYEAVLNVQRDCIKLCKASNNYSLHDI
HEKSITLMKQELKNLGIDKVSGWNVEKLYPHYIGHNLGLDVHDVPKVSRY
EPLKVGQVITIEPGLYIPNEESFPSYFRNVGIRIEDDIAIGEDTYTNLTV
EAVKEIDDLENVMQNGL
Ligand information
Ligand IDGLY
InChIInChI=1S/C2H5NO2/c3-1-2(4)5/h1,3H2,(H,4,5)
InChIKeyDHMQDGOQFOQNFH-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 1.5.0C(C(=O)O)N
CACTVS 3.341NCC(O)=O
ACDLabs 10.04O=C(O)CN
FormulaC2 H5 N O2
NameGLYCINE
ChEMBLCHEMBL773
DrugBankDB00145
ZINCZINC000004658552
PDB chain6a9t Chain A Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB6a9t Crystal structures and biochemical analyses of intermediate cleavage peptidase: role of dynamics in enzymatic function.
Resolution2.15 Å
Binding residue
(original residue number in PDB)		Y296 D327 D338 H417 H424 E444 E467
Binding residue
(residue number reindexed from 1)		Y214 D245 D256 H335 H342 E362 E385
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.11.26: intermediate cleaving peptidase 55.
Gene Ontology
Molecular Function
GO:0030145 manganese ion binding
GO:0070006 metalloaminopeptidase activity

View graph for
Molecular Function
External links
PDB RCSB:6a9t, PDBe:6a9t, PDBj:6a9t
PDBsum6a9t
PubMed30582634
UniProtP40051|ICP55_YEAST Intermediate cleaving peptidase 55 (Gene Name=ICP55)

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