Structure of PDB 6a46 Chain A Binding Site BS03

Receptor Information

>6a46 Chain A (length=223) Species: 10090 (Mus musculus)

EPPRAETFVFLDLEATGLPNMDPEIAEISLFAVHRSSLENPERDDSGSLV
LPRVLDKLTLCMCPERPFTAKASEITGLSSESLMHCGKAGFNGAVVRTLQ
GFLSRQEGPICLVAHNGFDYDFPLLCTELQRLGAHLPQDTVCLDTLPALR
GLDRAHSRKSYSLASLFHRYFQAEPSAAHSAEGDVHTLLLIFLHRAPELL
AWADEQARSWAHIEPMYVPPDGP

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 6a46 Chain A Residue 304

Receptor-Ligand Complex Structure

Structure summary

• PDB: 6a46 Structural insights into the duplex DNA processing of TREX2
• Resolution: 2.0 Å
• Binding residue (original residue number in PDB): S171 L172
• Binding residue (residue number reindexed from 1): S162 L163
• Annotation score: 4

Enzymatic activity

• Enzyme Commision number: 3.1.11.2: exodeoxyribonuclease III.

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0003676 nucleic acid binding
• GO:0004527 exonuclease activity
• GO:0008296 3'-5'-DNA exonuclease activity
• GO:0008311 double-stranded DNA 3'-5' DNA exonuclease activity
• GO:0008408 3'-5' exonuclease activity
• GO:0042803 protein homodimerization activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006259 DNA metabolic process
• GO:0006281 DNA repair

Cellular Component

• GO:0005634 nucleus

External links

• PDB: RCSB:6a46, PDBe:6a46, PDBj:6a46
• PDBsum: 6a46
• PubMed: 30357414
• UniProt: Q9R1A9|TREX2_MOUSE Three prime repair exonuclease 2 (Gene Name=Trex2)