Structure of PDB 5zyw Chain A Binding Site BS03

Receptor Information

>5zyw Chain A (length=233) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

QNWFPIFNPERSDKPSVPLKIPLQRNVIPSVTRVLQQTMTKQQVFLLERW
KQRMILELGEDGFKEYTSNVFLQGKRFHEALESILSPNLLKSGYIESVQH
ILKDVSGVRALESAVQHETLNYIGLLDCVAEYQGKLCVIDWKTSEKPKPF
IQSTFDNPLQVVAYMGAMNHDTNYSFQVQCGLIVVAYKDGSPAHPHFMDA
ELCSQYWTKWLLRLEEYTEKKKNQNIQKPEYSE

Ligand information

Ligand ID

InChI

InChI=1S/Mn/q+2

InChIKey

WAEMQWOKJMHJLA-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 OpenEye OEToolkits 1.5.0	[Mn+2]
CACTVS 3.341	[Mn++]

Formula

Name

MANGANESE (II) ION

PDB chain

5zyw Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5zyw Structural insights into DNA degradation by human mitochondrial nuclease MGME1
Resolution	2.2 Å
Binding residue (original residue number in PDB)	T134 S343
Binding residue (residue number reindexed from 1)	T32 S232
Annotation score	4

Enzymatic activity

Enzyme Commision number

3.1.-.-

External links

PDB	RCSB:5zyw, PDBe:5zyw, PDBj:5zyw
PDBsum	5zyw
PubMed	30247721
UniProt	Q9BQP7\|MGME1_HUMAN Mitochondrial genome maintenance exonuclease 1 (Gene Name=MGME1)

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