Structure of PDB 5z6w Chain A Binding Site BS03

Receptor Information
>5z6w Chain A (length=546) Species: 208964 (Pseudomonas aeruginosa PAO1) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PALPEPFYYLHNFRAVLAWIGERYADLLDDQERAFIAAFAELPEASQALL
VRMVMRKGTLFREGKLAYAEIGDTRAAVQPLLALGWVDAQPTLELAQLFG
LLKKDELSQLFRDHLGRANLRKDALLERLQPLFPEARRLAEWQADFAEPV
YELRCMALCDRLRLMYFGNLWQDWSEFVLADLGIYRYESVEFSADSRGFR
LRADVDAYLHLFDCRQRFDLGEPLEELLAGLPGEPYANPWLEGRRVKLLF
QFAQHCEKQRDFDLAQRLYRQSSHPGARLRAIRSLERGERFAEAHALARE
ASCAPESDAERQGLARLLPRLQGKLGLPRQARAAAPEIDRLDLCLAFPSE
PCSVEWAVREHLEEPGCAVHYVENGLINSLFGLLCWEAIFAAIPGAFFHP
FHSAPADLHSADFRQRRAALFEACLGRLEDGSYRDAIRCRYRDKFGLQSP
FVYWELLGEELLEQALDCLPAAHLRAWFERLLEDIPGNRAGLPDLIQFWP
AQRRYRMVEVKGPGDRLQDNQLRWLQFCREREMPVAVCYVRWHVDD
Ligand information
Ligand IDMN
InChIInChI=1S/Mn/q+2
InChIKeyWAEMQWOKJMHJLA-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mn+2]
CACTVS 3.341[Mn++]
FormulaMn
NameMANGANESE (II) ION
ChEMBL
DrugBankDB06757
ZINC
PDB chain5z6w Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5z6w Structural mechanism of DNA interstrand cross-link unhooking by the bacterial FAN1 nuclease.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		E386 D507
Binding residue
(residue number reindexed from 1)		E373 D494
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.4.1: phosphodiesterase I.
Gene Ontology
Molecular Function
GO:0000287 magnesium ion binding
GO:0003676 nucleic acid binding
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0004527 exonuclease activity
GO:0004528 phosphodiesterase I activity
GO:0008409 5'-3' exonuclease activity
GO:0016788 hydrolase activity, acting on ester bonds
GO:0017108 5'-flap endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
GO:0070336 flap-structured DNA binding
Biological Process
GO:0006281 DNA repair
GO:0036297 interstrand cross-link repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5z6w, PDBe:5z6w, PDBj:5z6w
PDBsum5z6w
PubMed29514982
UniProtQ9I2N0|FAN1_PSEAE Fanconi-associated nuclease 1 homolog (Gene Name=fan1)

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