Structure of PDB 5xus Chain A Binding Site BS03

Receptor Information

>5xus Chain A (length=1206) Species: 1410628 (Lachnospiraceae bacterium ND2006)

HMSKLEKFTNCYSLSKTLRFKAIPVGKTQENIDNKRLLVEDEKRAEDYKG
VKKLLDRYYLSFINDVLHSIKLKNLNNYISLFRKKTRTEKENKELENLEI
NLRKEIAKAFKGNEGYKSLFKKDIIETILPEFLDDKDEIALVNSFNGFTT
AFTGFFDNRENMFSEEAKSTSIAFRCINENLTRYISNMDIFEKVDAIFDK
HEVQEIKEKILNSDYDVEDFFEGEFFNFVLTQEGIDVYNAIIGGFVTESG
EKIKGLNEYINLYNQKTKQKLPKFKPLYKQVLSDRESLSFYGEGYTSDEE
VLEVFRNTLNKNSEIFSSIKKLEKLFKNFDEYSSAGIFVKNGPAISTISK
DIFGEWNVIRDKWNAEYDDIHLVTEKYEDDRRKSFKKIGSFSLEQLQEYA
DADLSVVEKLKEIIIQKVDEIYKVYGSSEKLFDADFVLEKSLKKNDAVVA
IMKDLLDSVKSFENYIKAFFGEGKETNRDESFYGDFVLAYDILLKVDHIY
DAIRNYVTQKPYSKDKFKLYFQNPQFMGGWDKDKETDYRATILRYGSKYY
LAIMDKKYAKCLQKIDKDDVNGNYEKINYKLLPGPNKMLPKVFFSKKWMA
YYNPSEDIQKIYKNGTFKKGDMFNLNDCHKLIDFFKDSISRYPKWSNAYD
FNFSETEKYKDIAGFYREVEEQGYKVSFESASKKEVDKLVEEGKLYMFQI
YNKDFSDKSHGTPNLHTMYFKLLFDENNHGQIRLSGGAELFMRRASLKKE
ELVVHPANSPIANKNPDNPKKTTTLSYDVYKDKRFSEDQYELHIPIAINK
CPKNIFKINTEVRVLLKHDDNPYVIGIDRGERNLLYIVVVDGKGNIVEQY
SLNEIINNFNGIRIKTDYHSLLDKKEKERFEARQNWTSIENIKELKAGYI
SQVVHKICELVEKYDAVIALEDLNVKVEKQVYQKFEKMLIDKLNYMVDKK
SNPCATGGALKGYQITNKFESFKSMSTQNGFIFYIPAWLTSKIDPSTGFV
NLLKTKYTSIADSKKFISSFDRIMYVPEEDLFEFALDYKNFSRTDADYIK
KWKLYSYGNRIRIFDWEEVCLTSAYKELFNKYGINYQQGDIRALLCEQSD
KAFYSSFMALMSLMLQMRNSITGRTDVDFLISPVKNSDGIFYDSRNYEAQ
ENAILPKNADANGAYNIARKVLWAIGQFKKAEDEKLDKVKIAISNKEWLE
YAQTSV

Ligand information

>5xus Chain D (length=9)

cgtccttta

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5xus Structural Basis for the Canonical and Non-canonical PAM Recognition by CRISPR-Cpf1.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): K120 K121 G146 T148 T149 Q529 K591 K595
• Binding residue (residue number reindexed from 1): K121 K122 G147 T149 T150 Q525 K587 K591

Gene Ontology

Molecular Function

• GO:0046872 metal ion binding

External links

• PDB: RCSB:5xus, PDBe:5xus, PDBj:5xus
• PDBsum: 5xus
• PubMed: 28781234
• UniProt: A0A182DWE3