Structure of PDB 5xp8 Chain A Binding Site BS03

Receptor Information
>5xp8 Chain A (length=678) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NHLGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVAR
RAGGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPK
DPGERSVLSALARRLLQERLRRLEGVWVEGLAVYRREHARGPGWRVLGGA
VLDLWVSDSGAFLLEVDPAYRILCEMSLEAWLAQGHPLPKRVRNAYDRRT
WELLRLGEEDPKELPLPGGLSLLDYHASKGRLQGREGGRVAWVADPKDPR
KPIPHLTGLLVPVLTLEDLHALSLPWEERRRRTREIASWIGRRLGLGTPE
AVRAQAYRLSIPKLMGRRAVSKPADALRVGFYRAQETALALLRLDGAQGW
PEFLRRALLRAFGASGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVL
VLTPPMAWEDRNRLKALLLREGLPSQILNVPLREEERHRWENALLGLLAK
AGLQVVALSGAYPAELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPE
AQAGERIPQEVVWDLLEETLWAFRRKAGRLPSRVLLLRDGRVPQDEFALA
LEALAREGIAYDLVSVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVH
RDFRGTPRPLKLVHEAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLH
LADRLVKEVGRLGIRHLKEVDREKLFFV
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5xp8 Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes.
Resolution3.1 Å
Binding residue
(original residue number in PDB)		Y197 L217 L223 Y226 H227 R232 I254 P255
Binding residue
(residue number reindexed from 1)		Y196 L216 L222 Y225 H226 R231 I253 P254
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:5xp8, PDBe:5xp8, PDBj:5xp8
PDBsum5xp8
PubMed28911094
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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