Structure of PDB 5xou Chain A Binding Site BS03

Receptor Information
>5xou Chain A (length=564) Species: 262724 (Thermus thermophilus HB27) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LGKTEVFLNRFALRPLNPEELRPWRLEVVLDPPPGREEVYPLLAQVARRA
GGVTVRMGDGLASWSPPEVLVLEGTLARMGQTYAYRLYPKGRRPLDPKDP
GERSVLSALARRLLQERLRRLEGVWVEGLAVYRREVLGGAVLDLWVSDSG
AFLLEVDPALPWEERRRRTREIASWIGRRLGLGTPEAVRAQAYRLSIPKL
MGRRAVSKPADALRVGFYRAQETALALLRLDGAQGWPEFLRRALLRAFGA
SGASLRLHTLHAHPSQGLAFREALRKAKEEGVQAVLVLTPPMAWEDRNRL
KALLLREGLPSQILNVPLREEERHRWENALLGLLAKAGLQVVALSGAYPA
ELAVGFDAGGRESFRFGGAACAVGGDGGHLLWTLPEAQAGERIPQEVVWD
LLEETLWAFRRKAGRLPSRVLLLRNGRVPQDEFALALEALAREGIAYDLV
SVRKSGGGRVYPVQGRLADGLYVPLEDKTFLLLTVHRDFRGTPRPLKLVH
EAGDTPLEALAHQIFHLTRLYPASGFAFPRLPAPLHLADRLVKEVGRLGI
RHLKEVDREKLFFV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5xou Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5xou Structure/cleavage-based insights into helical perturbations at bulge sites within T. thermophilus Argonaute silencing complexes
Resolution2.63 Å
Binding residue
(original residue number in PDB)		Q433 V685
Binding residue
(residue number reindexed from 1)		Q312 V564
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.24.-
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
GO:0004520 DNA endonuclease activity
GO:0030145 manganese ion binding
GO:0046872 metal ion binding
Biological Process
GO:0006260 DNA replication
GO:0044355 clearance of foreign intracellular DNA

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Molecular Function
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Biological Process
External links
PDB RCSB:5xou, PDBe:5xou, PDBj:5xou
PDBsum5xou
PubMed28911094
UniProtQ746M7|AGO_THET2 Protein argonaute (Gene Name=ago)

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