Structure of PDB 5xjb Chain A Binding Site BS03

Receptor Information
>5xjb Chain A (length=341) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
PNWEFARMIKEFRVTMECSPLTVTDPIEEHRICVCVRKRPLNKQELAKKE
IDVISVPSKCLLLVHEPKLKVDLTKYLENQAFCFDFAFDETASNEVVYRF
TARPLVQTIFEGGKATCFAYGQTGSGKTHTMGGQNASKGIYAMASRDVFL
LKNQPRYRNLNLEVYVTFFEIYNGKVFDLLNKKAKLRVLEDSRQQVQVVG
LQEYLVTCADDVIKMINMGSACRTSGQSSRSHACFQILLRTKGRLHGKFS
LVDLAGNERGADRMEGAEINKSLLALKECIRALGQNKHTPFRESKLTQVL
RDSFIGENSRTCMIAMISPGISSCEYTLNTLRYADRVKELS
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5xjb Chain A Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5xjb Mechanism of Catalytic Microtubule Depolymerization via KIF2-Tubulin Transitional Conformation
Resolution3.1 Å
Binding residue
(original residue number in PDB)		T351 S463
Binding residue
(residue number reindexed from 1)		T128 S228
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003777 microtubule motor activity
GO:0005524 ATP binding
GO:0008017 microtubule binding
Biological Process
GO:0007018 microtubule-based movement

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5xjb, PDBe:5xjb, PDBj:5xjb
PDBsum5xjb
PubMed28903043
UniProtQ922S8|KIF2C_MOUSE Kinesin-like protein KIF2C (Gene Name=Kif2c)

[Back to BioLiP]