Structure of PDB 5xem Chain A Binding Site BS03

Receptor Information

>5xem Chain A (length=302) Species: 190304 (Fusobacterium nucleatum subsp. nucleatum ATCC 25586)

SLANSVIDLIGNTPLVKINNIDTFGNEIYVKLEGSNPGRSTKDRIALKMI
EEAEKEGLIDKDTVIIEATSGNTGIGLAMICAVKNYKLKIVMPDTMSIER
IQLMRAYGTEVILTDGSLGMKACLEKLEELKKNEKKYFVPNQFTNVNNPK
AHYETTAEEILKDLNNKVDVFICGTGTGGSFSGTAKKLKEKLPNIKTFPV
EPASSPLLSKGYIGPHKIQGMGMSIGGIPAVYDGSLADDILVCEDDDAFE
MMRELSFKEGILGGISTGATFKAALDYSKENADKGLKIVVLSTDSGEKYL
SN

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 5xem Chain A Residue 510

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5xem Purification, crystallization and preliminary X-ray analysis of two hydrogen sulfide-producing enzymes from Fusobacterium nucleatum.
• Resolution: 1.84 Å
• Binding residue (original residue number in PDB): L300 S301 N302
• Binding residue (residue number reindexed from 1): L300 S301 N302
• Annotation score: 1

Enzymatic activity

• Enzyme Commision number: 2.5.1.47: cysteine synthase.

Gene Ontology

Molecular Function

• GO:0004124 cysteine synthase activity
• GO:0016740 transferase activity
• GO:0046872 metal ion binding
• GO:0080146 L-cysteine desulfhydrase activity

Biological Process

• GO:0006534 cysteine metabolic process
• GO:0006535 cysteine biosynthetic process from serine
• GO:0009069 serine family amino acid metabolic process
• GO:0044272 sulfur compound biosynthetic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5xem, PDBe:5xem, PDBj:5xem
• PDBsum: 5xem
• UniProt: Q8RE94