Structure of PDB 5x9h Chain A Binding Site BS03

Receptor Information

>5x9h Chain A (length=427) Species: 300852 (Thermus thermophilus HB8)

EVLEEIHPQDLLALWDELKGEHRYVVLTLLPKAKAAEVLSHLSPEEQAEY
LKTLPPWRLREILEELSLDDLADALQAVRKEDPAYFQRLKDLLDPRTRAE
VEALARYEEDEAGGLMTPEYVAVREGMTVEEVLRFLRRAAPDAETIYYIY
VVDEKGRLKGVLSLRDLIVADPRTRVAEIMNPKVVYVRTDTDQEEVARLM
ADYDFTVLPVVDEEGRLVGIVTVDDVLDVLEAEATEDIHKLGAVDVPDLV
YSEAGPVALWLARVRWLVILILTGMVTSSILQGFESVLEAVTALAFYVPV
LLGTGGNTGNQSATLIIRALATRDLDLRDWRRVFLKEMGVGLLLGLTLSF
LLVGKVYWDGHPLLLPVVGVSLVLIVFFANLVGAMLPFLLRRLGVDPALV
SNPLVATLSDVTGLLIYLSVARLLLEA

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5x9h Chain A Residue 506

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5x9h ATP-dependent modulation of MgtE in Mg(2+) homeostasis
• Resolution: 3.598 Å
• Binding residue (original residue number in PDB): A223 D226
• Binding residue (residue number reindexed from 1): A201 D204
• Annotation score: 5

Gene Ontology

Molecular Function

• GO:0000287 magnesium ion binding
• GO:0008324 monoatomic cation transmembrane transporter activity
• GO:0015095 magnesium ion transmembrane transporter activity
• GO:0042802 identical protein binding
• GO:0042803 protein homodimerization activity
• GO:0046872 metal ion binding

Biological Process

• GO:0006812 monoatomic cation transport
• GO:0015693 magnesium ion transport
• GO:1903830 magnesium ion transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5x9h, PDBe:5x9h, PDBj:5x9h
• PDBsum: 5x9h
• PubMed: 28747715
• UniProt: Q5SMG8|MGTE_THET8 Magnesium transporter MgtE (Gene Name=mgtE)