Structure of PDB 5wn2 Chain A Binding Site BS03

Receptor Information
>5wn2 Chain A (length=276) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ALYEDPPDQKTSPSGKPATLKICSWNVDGLRAWIKKKGLDWVKEEAPDIL
CLQQTKCSENKLPAELQELPGLSHQYWSAPSDKEGYSGVGLLSRQAPLKV
SYGIGDEEHDQEGRVIVAEFDSFVLVTAYVPNAGRGLVRLEYRQRWDEAF
RKFLKGLASRKPLVLCGNLNVAHEEIDLRNPKGNKKNAGFTPQERQGFGE
LLQAVPLADSFRHLYPNTPYAYTFWTYMMNARSKNVGWRLDYFLLSHSLL
PALCDSKIRSKALGSDHCPITLYLAL
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5wn2 Molecular snapshots of APE1 proofreading mismatches and removing DNA damage.
Resolution2.288 Å
Binding residue
(original residue number in PDB)		G71 R73 A74 K78 K98 Y269 M270
Binding residue
(residue number reindexed from 1)		G29 R31 A32 K36 K56 Y227 M228
Enzymatic activity
Catalytic site (original residue number in PDB) N68 Q96 N210 N212 D283 D308 H309
Catalytic site (residue number reindexed from 1) N26 Q54 N168 N170 D241 D266 H267
Enzyme Commision number 3.1.11.2: exodeoxyribonuclease III.
3.1.21.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
Biological Process
GO:0006281 DNA repair

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Molecular Function
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Biological Process
External links
PDB RCSB:5wn2, PDBe:5wn2, PDBj:5wn2
PDBsum5wn2
PubMed29374164
UniProtP27695|APEX1_HUMAN DNA repair nuclease/redox regulator APEX1 (Gene Name=APEX1)

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