Structure of PDB 5wj8 Chain A Binding Site BS03

Receptor Information
>5wj8 Chain A (length=210) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
AVQFSNASYEAAILENLALGTEIVRVQAYSIDNLNQITYRFNAYTSTQAK
ALFKIDAITGVITVQGLVDREKGDFYTLTVVADDGGPKVDSTVKVYITVL
DENDNSPRFDFTSDSAVSIPEDCPVGQRVATVKAWDPDAGSNGQVVFSLA
SGNIAGAFEIVTTNDSIGEVFVARPLDREELDHYILQVVASDRGTPPRKK
DHILQVTILD
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5wj8 Chain A Residue 1603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5wj8 Zooming in on Cadherin-23: Structural Diversity and Potential Mechanisms of Inherited Deafness.
Resolution1.86 Å
Binding residue
(original residue number in PDB)		E1301 E1357 D1387 E1388 D1390 D1424
Binding residue
(residue number reindexed from 1)		E15 E71 D101 E102 D104 D138
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding
Biological Process
GO:0007155 cell adhesion
GO:0007156 homophilic cell adhesion via plasma membrane adhesion molecules
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5wj8, PDBe:5wj8, PDBj:5wj8
PDBsum5wj8
PubMed30033219
UniProtQ9H251|CAD23_HUMAN Cadherin-23 (Gene Name=CDH23)

[Back to BioLiP]