Structure of PDB 5uzw Chain A Binding Site BS03

Receptor Information
>5uzw Chain A (length=686) Species: 39387 (Gypsophila vaccaria) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
YPPVRRDETVVDDYFGVKVADPYRWLEDPNSEETKEFVDNQEKLANSVLE
ECELIDKFKQKIIDFVNFPRCGVPFRRANKYFHFYNSGLQAQNVFQMQDD
LDGKPEVLYDPNLREGGRSGLSLYSVSEDAKYFAFGIHSGLTEWVTIKIL
KTEDRSYLPDTLEWVKFSPAIWTHDNKGFFYCPYPPNQEARYHFLGTDQS
EDILLWRDLENPAHHLKCQITDDGKYFLLYILDGCDDANKVYCLDLTKLP
NGLESFAPFMKLIDSFDASYTAIANDGSVFTFQTNKDAPRKKLVRVDLNN
PSVWTDLVPESKKDLLESAHAVNENQLILRYLSDVKHVLEIRDLESGALQ
HRLPIDIGSVDGITARRRDSVVFFKFTSILTPGIVYQCDLKNDPTQLKIF
RESVVPDFDRSEFEVKQVFVPSKDGTKIPIFIAARKGISLDGSHPCEMHG
YGGFGINMMPTFSASRIVFLKHLGGVFCLANIRGGGEYGEEWHKAGFRDK
KQNVFDDFISAAEYLISSGYTKARRVAIEGGSNGGLLVAACINQRPDLFG
CAEANCGVMDMLRFHKFTLGYLWTGDYGCSDKEEEFKWLIKYSPIHNVRR
PWEQPGNEETQYPATMILTADHDDRVVPLHSFKLLATMQHVLCTSLEDSP
QKNPIIARIQRATMTQIAEVADRYGFMAKALEAPWI
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5uzw Chain A Residue 802 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5uzw Characterization of the macrocyclase involved in the biosynthesis of RiPP cyclic peptides in plants.
Resolution2.82 Å
Binding residue
(original residue number in PDB)		A718 E720
Binding residue
(residue number reindexed from 1)		A680 E682
Annotation score4
Enzymatic activity
Catalytic site (original residue number in PDB) Y481 S562 D653
Catalytic site (residue number reindexed from 1) Y451 S532 D623
Enzyme Commision number 3.4.21.-
3.4.21.26: prolyl oligopeptidase.
Gene Ontology
Molecular Function
GO:0004252 serine-type endopeptidase activity
GO:0008236 serine-type peptidase activity
GO:0046872 metal ion binding
GO:0070012 oligopeptidase activity
Biological Process
GO:0006508 proteolysis
Cellular Component
GO:0005829 cytosol

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uzw, PDBe:5uzw, PDBj:5uzw
PDBsum5uzw
PubMed28584123
UniProtR4P353

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