Structure of PDB 5um3 Chain A Binding Site BS03

Receptor Information
>5um3 Chain A (length=72) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSLCGRVFKVGEPTYSCRDCAVDPTCLLCMECFLGSIHRDHRYRMTTSGG
GGFCDCGDTEAWKEGPYCQKHE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5um3 Chain A Residue 203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5um3 Bound Waters Mediate Binding of Diverse Substrates to a Ubiquitin Ligase.
Resolution1.198 Å
Binding residue
(original residue number in PDB)		C112 C115 H133 H136
Binding residue
(residue number reindexed from 1)		C17 C20 H38 H41
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0008270 zinc ion binding
GO:0061630 ubiquitin protein ligase activity
Biological Process
GO:0071596 ubiquitin-dependent protein catabolic process via the N-end rule pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5um3, PDBe:5um3, PDBj:5um3
PDBsum5um3
PubMed28392261
UniProtQ8IWV8|UBR2_HUMAN E3 ubiquitin-protein ligase UBR2 (Gene Name=UBR2)

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