Structure of PDB 5uk5 Chain A Binding Site BS03

Receptor Information
>5uk5 Chain A (length=194) Species: 10116 (Rattus norvegicus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ECQLMPNACQNGGTCHNSHGGYNCVCVNGWTGEDCSENIDDCASAACFQG
ATCHDRVASFYCECPHGRTGLLCHLNDACISNPCNEGSNCDTNPVNGKAI
CTCPSGYTGPACSQDVDECALGANPCEHAGKCLNTLGSFECQCLQGYTGP
RCEIDVNECISNPCQNDATCLDQIGEFQCICMPGYEGVYCESGR
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5uk5 Chain A Residue 601 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5uk5 Notch-Jagged complex structure implicates a catch bond in tuning ligand sensitivity.
Resolution2.506 Å
Binding residue
(original residue number in PDB)		N335 I336 D338 D352 R353
Binding residue
(residue number reindexed from 1)		N38 I39 D41 D55 R56
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005509 calcium ion binding

View graph for
Molecular Function
External links
PDB RCSB:5uk5, PDBe:5uk5, PDBj:5uk5
PDBsum5uk5
PubMed28254785
UniProtQ07008|NOTC1_RAT Neurogenic locus notch homolog protein 1 (Gene Name=Notch1)

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