Structure of PDB 5uc6 Chain A Binding Site BS03

Receptor Information
>5uc6 Chain A (length=151) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NVKYNFMRIIKYEFILNDALNQSIIRANDQYLTAAALHNLDEAVKFDMGA
YKSSKDDAKITVILRISKTQLYVTAQDEDQPVLLKEMPEIPKTITGSETN
LLFFWETHGTKNYFTSVAHPNLFIATKQDYWVCLAGGPPSITDFQILENQ
A
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5uc6 Chain A Residue 203 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5uc6 Structural basis for IL-1 alpha recognition by a modified DNA aptamer that specifically inhibits IL-1 alpha signaling.
Resolution2.1 Å
Binding residue
(original residue number in PDB)		Y121 F122 T150 F152
Binding residue
(residue number reindexed from 1)		Y113 F114 T142 F144
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005125 cytokine activity
GO:0005149 interleukin-1 receptor binding
Biological Process
GO:0006954 inflammatory response
GO:0006955 immune response
Cellular Component
GO:0005576 extracellular region
GO:0005615 extracellular space

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5uc6, PDBe:5uc6, PDBj:5uc6
PDBsum5uc6
PubMed28993621
UniProtP01583|IL1A_HUMAN Interleukin-1 alpha (Gene Name=IL1A)

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