Structure of PDB 5u33 Chain A Binding Site BS03

Receptor Information
>5u33 Chain A (length=1085) Species: 1356854 (Alicyclobacillus acidoterrestris ATCC 49025) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMAVKSIKVKLRLDDMPEIRAGLWKLHKEVNAGVRYYTEWLSLLRQENLY
RRSPNGDGEQECDKTAEECKAELLERLRARQVENGHRGPAGSDDELLQLA
RQLYELLVPQAIGAKGDAQQIARKFLSPLADKDAVGGLGIAKAGNKPRWV
RMREAGEWEEEKEKAETRKSADRTADVLRALADFGLKPLMRVYTDSEMSS
VEWKPLRKGQAVRTWDRDMFQQAIERMMSWESWNQRVGQEYAKLVEQKNR
FEQKNFVGQEHLVHLVNQLQQDMKEASPGLESKEQTAHYVTGRALRGSDK
VFEKWGKLAPDAPFDLYDAEIKNVQRRNTRRFGSHDLFAKLAEPEYQALW
REDASFLTRYAVYNSILRKLNHAKMFATFTLPDATAHPIWTRFDKLGGNL
HQYTFLFNEFGERRHAIRFHKLLKVENGVAREVDDVTVPISMSEQLDNLL
PRDPNEPIALYFRDYGAEQHFTGEFGGAKIQCRRDQLAHMHRRRRDVYLN
VSVRVQSQSEARGERRPPYAAVFRLVGDNHRAFVHFDKLSDYLAEHPDDG
KLGSEGLLSGLRVMSVALGLRTSASISVFRVARKDELKPNSKGRVPFFFP
IKGNDNLVAVHERSQLLKLPGETESKDLRAIREERQRTLRQLRTQLAYLR
LLVRCGSEDVGRRERSWAKLIEQPVDAANHMTPDWREAFENELQKLKSLH
GICSDKEWMDAVYESVRRVWRHMGKQVRDWRKDVRSGERPKIRGYAKDVV
GGNSIEQIEYLERQYKFLKSWSFFGKVSGQVIRAEKGSRFAITLREHIDH
AKEDRLKKLADRIIMEALGYVYALDERGKGKWVAKYPPCQLILLAELSEY
QFNNDRPPSENNQLMQWSHRGVFQELINQAQVHDLLVGTMYAAFSSRFDA
RTGAPGIRCRRVPARCTQEHNPEPFPWWLNKFVVEHTLDACPLRADDLIP
TGEGEIFVSPFSAEEGDFHQIHAALNAAQNLQQRLWSDFDISQIRLRCDW
GEVDGELVLIPRLTGKRTADSYSNKVFYTNTGVTYYERERGREKSVVLMR
DPSGIINRGNWTRQKEFWSMVNQRIEGYLVKQIRS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5u33 PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease.
Resolution3.75 Å
Binding residue
(original residue number in PDB)		Q119 R122 K123 V134 G135 G136 A140 G143 N144 P146 R147 R150 K165 R169 Q211 V213 R218 R332 Q403 L573 R574 Y853 Q866 W870 F897 S899 R900 R911 E956
Binding residue
(residue number reindexed from 1)		Q120 R123 K124 V135 G136 G137 A141 G144 N145 P147 R148 R151 K164 R168 Q210 V212 R217 R331 Q402 L570 R571 Y850 Q863 W867 F894 S896 R897 R908 E953
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
Biological Process
GO:0051607 defense response to virus

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Molecular Function
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Biological Process
External links
PDB RCSB:5u33, PDBe:5u33, PDBj:5u33
PDBsum5u33
PubMed27984729
UniProtT0D7A2|CS12B_ALIAG CRISPR-associated endonuclease Cas12b (Gene Name=cas12b)

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