Structure of PDB 5u30 Chain A Binding Site BS03

Receptor Information
>5u30 Chain A (length=1085) Species: 1356854 (Alicyclobacillus acidoterrestris ATCC 49025) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SMAVKSIKVKLRLDDMPEIRAGLWKLHKEVNAGVRYYTEWLSLLRQENLY
RRSPNGDGEQECDKTAEECKAELLERLRARQVENGHRGPAGSDDELLQLA
RQLYELLVPQAIGAKGDAQQIARKFLSPLADKDAVGGLGIAKAGNKPRWV
RMREAGEWEEEKEKAETRKSADRTADVLRALADFGLKPLMRVYTDSEMSS
VEWKPLRKGQAVRTWDRDMFQQAIERMMSWESWNQRVGQEYAKLVEQKNR
FEQKNFVGQEHLVHLVNQLQQDMKEASPGLESKEQTAHYVTGRALRGSDK
VFEKWGKLAPDAPFDLYDAEIKNVQRRNTRRFGSHDLFAKLAEPEYQALW
REDASFLTRYAVYNSILRKLNHAKMFATFTLPDATAHPIWTRFDKLGGNL
HQYTFLFNEFGERRHAIRFHKLLKVENGVAREVDDVTVPISMSEQLDNLL
PRDPNEPIALYFRDYGAEQHFTGEFGGAKIQCRRDQLAHMHRRRRDVYLN
VSVRVQSQSEARGERRPPYAAVFRLVGDNHRAFVHFDKLSDYLAEHPDDG
KLGSEGLLSGLRVMSVALGLRTSASISVFRVARKDELKPNSKGRVPFFFP
IKGNDNLVAVHERSQLLKLPGETESKDLRAIREERQRTLRQLRTQLAYLR
LLVRCGSEDVGRRERSWAKLIEQPVDAANHMTPDWREAFENELQKLKSLH
GICSDKEWMDAVYESVRRVWRHMGKQVRDWRKDVRSGERPKIRGYAKDVV
GGNSIEQIEYLERQYKFLKSWSFFGKVSGQVIRAEKGSRFAITLREHIDH
AKEDRLKKLADRIIMEALGYVYALDERGKGKWVAKYPPCQLILLAELSEY
QFNNDRPPSENNQLMQWSHRGVFQELINQAQVHDLLVGTMYAAFSSRFDA
RTGAPGIRCRRVPARCTQEHNPEPFPWWLNKFVVEHTLDACPLRADDLIP
TGEGEIFVSPFSAEEGDFHQIHAALNAAQNLQQRLWSDFDISQIRLRCDW
GEVDGELVLIPRLTGKRTADSYSNKVFYTNTGVTYYERERGREKSVVLMR
DPSGIINRGNWTRQKEFWSMVNQRIEGYLVKQIRS
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5u30 PAM-Dependent Target DNA Recognition and Cleavage by C2c1 CRISPR-Cas Endonuclease.
Resolution2.92 Å
Binding residue
(original residue number in PDB)		Q119 R122 A133 V134 G135 G136 A140 A142 G143 N144 R147 Q211 V213 R218
Binding residue
(residue number reindexed from 1)		Q120 R123 A134 V135 G136 G137 A141 A143 G144 N145 R148 Q210 V212 R217
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0004519 endonuclease activity
Biological Process
GO:0051607 defense response to virus

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5u30, PDBe:5u30, PDBj:5u30
PDBsum5u30
PubMed27984729
UniProtT0D7A2|CS12B_ALIAG CRISPR-associated endonuclease Cas12b (Gene Name=cas12b)

[Back to BioLiP]