Structure of PDB 5too Chain A Binding Site BS03

Receptor Information
>5too Chain A (length=517) Species: 238 (Elizabethkingia meningoseptica) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
NAVPRPKLVVGLVVDQMRWDYLYRYYSKYGEGGFKRMLNTGYSLNNVHID
YVPTVSAIGHTSIFTGSVPSIHGIAGADWYDKELGKSVYCTSDETVQPVG
TTSNSVGQHSPRNLWSTTVTDQLGLATNFTSKVVGVSLADAASILPAGHN
PTGAFWFDDTTGKFITSTYYTKELPKWVNDFNNKNVPAQLVANGWNTLLP
INQYTESSEDNVEWEGLLGSKKTPTFPYTDLAKDYEAKKGLIRTTPFGNT
LTLQMADAAIDGNQMGVDDITDFLTVNLASTDYVGHNFGPNSIEVEDTYL
RLDRDLADFFNNLDKKVGKGNYLVFLSADHGAAHSVGFMQAHKMPTGFFM
KKEMNAKLKQKFGADNIIAAAMNYQVYFDRKVLADSKLELDDVRDYVMTE
LKKEPSVLYVLSTDEIWESSIPEPIKSRVINGYNWKRSGDIQIISKDGYL
SSKKGTTHSVWNSYDSHIPLLFMGWGIKQGESNQPYHMTDIAPTVSSLLK
IQFPSGAVGKPITEVIG
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5too Chain A Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5too Differential catalytic promiscuity of the alkaline phosphatase superfamily bimetallo core reveals mechanistic features underlying enzyme evolution.
Resolution2.031 Å
Binding residue
(original residue number in PDB)		D233 E238 E317
Binding residue
(residue number reindexed from 1)		D210 E215 E294
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.3.1: alkaline phosphatase.
Gene Ontology
Molecular Function
GO:0004035 alkaline phosphatase activity

View graph for
Molecular Function
External links
PDB RCSB:5too, PDBe:5too, PDBj:5too
PDBsum5too
PubMed29070681
UniProtQ9KJX5|ALPH_ELIME Alkaline phosphatase PafA (Gene Name=pafA)

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