Structure of PDB 5t3f Chain A Binding Site BS03

Receptor Information

>5t3f Chain A (length=129) Species: 9031 (Gallus gallus)

KVFGRCELAAAMKRHGLDNYRGYSLGNWVCAAKFESNFNTQATNRNTDGS
TDYGILQINSRWWCNDGRTPGSRNLCNIPCSALLSSDITASVNCAKKIVS
DGNGMNAWVAWRNRCKGTDVQAWIRGCRL

Ligand information

• Ligand ID: SEY
• InChI: InChI=1S/CH4N2Se/c2-1(3)4/h(H4,2,3,4)
• InChIKey: IYKVLICPFCEZOF-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.370: NC(N)=[Se]
  OpenEye OEToolkits 1.7.6: C(=[Se])(N)N
  ACDLabs 12.01: [Se]=C(N)N
• Formula: C H4 N2 Se
• Name: selenourea
• ChEMBL: CHEMBL3187603
• PDB chain: 5t3f Chain A Residue 203

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5t3f Selenourea: a convenient phasing vehicle for macromolecular X-ray crystal structures.
• Resolution: 1.45 Å
• Binding residue (original residue number in PDB): R68 P70
• Binding residue (residue number reindexed from 1): R68 P70
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): E35 N46 D48 S50 D52 N59
• Catalytic site (residue number reindexed from 1): E35 N46 D48 S50 D52 N59
• Enzyme Commision number: 3.2.1.17: lysozyme.

Gene Ontology

Molecular Function

• GO:0003796 lysozyme activity
• GO:0005515 protein binding
• GO:0016231 beta-N-acetylglucosaminidase activity
• GO:0016798 hydrolase activity, acting on glycosyl bonds
• GO:0042802 identical protein binding

Biological Process

• GO:0016998 cell wall macromolecule catabolic process
• GO:0031640 killing of cells of another organism
• GO:0042742 defense response to bacterium
• GO:0050829 defense response to Gram-negative bacterium
• GO:0050830 defense response to Gram-positive bacterium

Cellular Component

• GO:0005576 extracellular region
• GO:0005615 extracellular space
• GO:0005737 cytoplasm
• GO:0005783 endoplasmic reticulum

External links

• PDB: RCSB:5t3f, PDBe:5t3f, PDBj:5t3f
• PDBsum: 5t3f
• PubMed: 27841370
• UniProt: P00698|LYSC_CHICK Lysozyme C (Gene Name=LYZ)