Structure of PDB 5olm Chain A Binding Site BS03

Receptor Information
>5olm Chain A (length=125) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSHMASAARLTMMWEEVTCPICLDPFVEPVSIECGHSFCQECISQVGKSV
CPVCRQRFLLKNLRPNRQLANMVNNLKEISQEARGERCAVHGERLHLFCE
KDGKALCWVCAQSRKHRDHAMVPLE
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5olm Chain A Residue 503 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5olm Intracellular antibody signalling is regulated by phosphorylation of the Fc receptor TRIM21.
Resolution1.95 Å
Binding residue
(original residue number in PDB)		C92 H95 C111 C114
Binding residue
(residue number reindexed from 1)		C88 H91 C107 C110
Annotation score4
Enzymatic activity
Enzyme Commision number 2.3.2.27: RING-type E3 ubiquitin transferase.
Gene Ontology
Molecular Function
GO:0004842 ubiquitin-protein transferase activity
GO:0008270 zinc ion binding
GO:0046872 metal ion binding
Biological Process
GO:0016567 protein ubiquitination

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:5olm, PDBe:5olm, PDBj:5olm
PDBsum5olm
PubMed29667579
UniProtP19474|RO52_HUMAN E3 ubiquitin-protein ligase TRIM21 (Gene Name=TRIM21)

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