Structure of PDB 5oc9 Chain A Binding Site BS03

Receptor Information
>5oc9 Chain A (length=607) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SFTPLVVIELAQDVKEETKEWLKNRIIAKKKDGGAQLLFRPLLQNLYLVG
ASKIRMLLGAEAVGLVKECNDNTMRAFTYRTRQNFKGFDDNNDDFLTMAE
CQFIIKHELENLRAKDEKMIPGYPQAKLYPGKSLLRRLLTSGIVIQVFPL
HDSEALKKLEDTWYLKYQPIDSIRGYFGETIALYFGFLEYFTFALIPMAV
IGLPYYLFVWEDYDKYVIFASFNLIWSTVILELWKRGCANMTYRWGTLLM
KRKFEEPRPGFHGVLGINSITGKEEPLYPSYKRQLRIYLVSLPFVCLCLY
FSLYVMMIYFDMEVWALGLHENSEWTSVLLYVPSIIYAIVIEIMNRLYRY
AAEFLTSWENHRLESAYQNHLILKVLVFNFLNCFASLFYIAFVLKDMKLL
RQSLATLLITSQILNQIMESFLPYWLQRKHGVRVKRKVQALKDATLYEQV
ILEKEMGTYLGTFDDYLELFLQFGYVSLFSCVYPLAAAFAVLNNFTEVNS
DALKMCRVFKRPFSEPSANIGVWQLAFETMSVISVVTNCALIGMSPQVNA
VFPESKADLILIVVAVEHALLALKFILAFAIPDKPRHIQMKLARLEFESL
EALKQQQ
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5oc9 Chain A Residue 703 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5oc9 The structural basis of lipid scrambling and inactivation in the endoplasmic reticulum scramblase TMEM16K.
Resolution3.2 Å
Binding residue
(original residue number in PDB)		E259 A610 I613 D615
Binding residue
(residue number reindexed from 1)		E232 A578 I581 D583
Annotation score1
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0005227 calcium-activated cation channel activity
GO:0005229 intracellularly calcium-gated chloride channel activity
GO:0005254 chloride channel activity
Biological Process
GO:0034220 monoatomic ion transmembrane transport
GO:0098655 monoatomic cation transmembrane transport
GO:1902476 chloride transmembrane transport
Cellular Component
GO:0005886 plasma membrane
GO:0016020 membrane
GO:0043231 intracellular membrane-bounded organelle

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5oc9, PDBe:5oc9, PDBj:5oc9
PDBsum5oc9
PubMed31477691
UniProtQ9NW15|ANO10_HUMAN Anoctamin-10 (Gene Name=ANO10)

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