Structure of PDB 5nth Chain A Binding Site BS03

Receptor Information

>5nth Chain A (length=537) Species: 5664 (Leishmania major)

SAMKRPRSNSIVEETAVSAYVQTCTNFKSNVTFTDISKVSCVAYHVLLVG
ALEQLRDNSLKSVLFYCPAVAEALQRVKAGSTVKTLAEVPGRKGYTEVMV
TALPATTSRTNCPYRADSMSEAVAAACGSVEEGEVLDVYVCAPAGSETAV
ANAVARAAPHSYTAKAGQATKAYMKQAMSLNVVMSSRAAFTQELVRGKSV
CVAELEAICTSVQLCQRLVDTPPCMLDTVVYAEIAAAYAAELGVDMTVIK
GDELREKGYGGIYAVGKCAQYPAHLVTLRYRNPNAAEGAKNIAMVGKGIV
YDCGGLALKPAAHMTNMKTDMGGSAGVFCAFIAVVRSMKMQRTHFSHIAN
ISVTLCLAENAIGPHSYRNDDVVVMKSGKSVEVMNTDAEGRIVLGDGVYY
ATGEQDFVPDVLIDMATLTGAQGVATGSKHAGVYASDAEAEKDMISAGLQ
SGDLCYPVLYCPEYHEEVYKSPCADMRNIANSSSSAGSSCGGYFVEQHLS
ERFRGPFVHVDMAYPTSNTAGATGYGVTLVFEFLRQH

Ligand information

• Ligand ID: MN
• InChI: InChI=1S/Mn/q+2
• InChIKey: WAEMQWOKJMHJLA-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mn+2]
  CACTVS 3.341: [Mn++]
• Formula: Mn
• Name: MANGANESE (II) ION
• DrugBank: DB06757
• PDB chain: 5nth Chain A Residue 603

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5nth Structural Characterization of Acidic M17 Leucine Aminopeptidases from the TriTryps and Evaluation of Their Role in Nutrient Starvation inTrypanosoma brucei.
• Resolution: 2.5 Å
• Binding residue (original residue number in PDB): D304 D389 E391
• Binding residue (residue number reindexed from 1): D302 D387 E389
• Annotation score: 4

Enzymatic activity

• Catalytic site (original residue number in PDB): K311 R393
• Catalytic site (residue number reindexed from 1): K309 R391
• Enzyme Commision number: 3.4.11.-

Gene Ontology

Molecular Function

• GO:0004177 aminopeptidase activity
• GO:0008233 peptidase activity
• GO:0030145 manganese ion binding
• GO:0046872 metal ion binding
• GO:0070006 metalloaminopeptidase activity

Biological Process

• GO:0006508 proteolysis
• GO:0019538 protein metabolic process

Cellular Component

• GO:0005737 cytoplasm

External links

• PDB: RCSB:5nth, PDBe:5nth, PDBj:5nth
• PDBsum: 5nth
• PubMed: 28815215
• UniProt: Q4QH17