Structure of PDB 5mw5 Chain A Binding Site BS03

Receptor Information
>5mw5 Chain A (length=258) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MGYFELQLSALRNVNGELLSGACCDGGCGHDECDTYVRVCLKEYQAKVTP
TGPCSYGHGATPVLGGNSFYLPDQDPGLVVIPFQFAWPRSFTLIVEAWDW
DNDTTPNEELLIERVSHAGMINPEDRWKSLHFSGHVAHLELQIRVRCDEN
YYSATCNKFCRPRNDFFGHYTCDQYGNKACMDGWMGKECKEAVCKQGCNL
LHGGCTVPGECRCSYGWQGRFCDECVPYPGCVHGSCVEPWQCNCETNWGG
LLCDKDLN
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5mw5 Chain A Residue 404 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5mw5 Structural and functional dissection of the interplay between lipid and Notch binding by human Notch ligands.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		C50 D51 D150 D152
Binding residue
(residue number reindexed from 1)		C24 D25 D99 D101
Annotation score4
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Biological Process
GO:0007154 cell communication
GO:0007219 Notch signaling pathway
GO:0007275 multicellular organism development
Cellular Component
GO:0016020 membrane

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Biological Process
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Cellular Component
External links
PDB RCSB:5mw5, PDBe:5mw5, PDBj:5mw5
PDBsum5mw5
PubMed28572448
UniProtQ9Y219|JAG2_HUMAN Protein jagged-2 (Gene Name=JAG2)

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