Structure of PDB 5mkq Chain A Binding Site BS03

Receptor Information
>5mkq Chain A (length=304) Species: 70601 (Pyrococcus horikoshii OT3) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKCKFCSREAYIKIHYPKMYLCEEHFKEYFERKVSRTIERYKLLTKDERI
LVAVSGGKDSAVTAYVLKKLGYNIECLHINLGISGYSEKSEEYAKKQCKL
IGAPLHIVRIKEILGYGIGEVKTRRPPCSYCGLTKRYIMNKFAYDNGFDA
IATGHNLDDEASFLLNNILHWNTEYLAKGGPILPQQGKFIKKVKPLYEVT
EREVVAYALAVGLEYIVEECPYGATTLDMKGVLNELEEKRPGTKFNFVRG
YLKKKKLFEPEIKEIKECKICRMPSSGDICAFCKFWGLKKEINFKVSSTD
EEPF
Ligand information
Ligand IDSF4
InChIInChI=1S/4Fe.4S
InChIKeyLJBDFODJNLIPKO-UHFFFAOYSA-N
SMILES
SoftwareSMILES
OpenEye OEToolkits 2.0.7[S]12[Fe]3[S]4[Fe]1[S]5[Fe]2[S]3[Fe]45
CACTVS 3.385S1[Fe]S[Fe]1.S2[Fe]S[Fe]2
FormulaFe4 S4
NameIRON/SULFUR CLUSTER
ChEMBL
DrugBank
ZINC
PDB chain5mkq Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5mkq Nonredox thiolation in tRNA occurring via sulfur activation by a [4Fe-4S] cluster.
Resolution2.79 Å
Binding residue
(original residue number in PDB)		C128 C131 K135 C220
Binding residue
(residue number reindexed from 1)		C128 C131 K135 C220
Annotation score1
Enzymatic activity
Enzyme Commision number 2.8.1.-
Gene Ontology
Molecular Function
GO:0000049 tRNA binding
GO:0005524 ATP binding
GO:0016740 transferase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0002098 tRNA wobble uridine modification
GO:0002143 tRNA wobble position uridine thiolation
GO:0008033 tRNA processing
GO:0034227 tRNA thio-modification
Cellular Component
GO:0002144 cytosolic tRNA wobble base thiouridylase complex

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5mkq, PDBe:5mkq, PDBj:5mkq
PDBsum5mkq
PubMed28655838
UniProtO58038|TTUA_PYRHO tRNA-5-methyluridine(54) 2-sulfurtransferase (Gene Name=ttuA)

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