Structure of PDB 5m6b Chain A Binding Site BS03

Receptor Information
>5m6b Chain A (length=548) Species: 5341 (Agaricus bisporus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
LLATVGPTGGVKNRLDIVDFVRDEKFFTLYVRALQAIQDKDQADYSSFFQ
LSGIHGLPFTPWAKPKDTPTVPYESGYCTHSQVLFPTWHRVYVSIYEQVL
QEAAKGIAKKFTVHKKEWAQAAEDLRQPYWDTGFALVPPDEIIKLEQVKI
TNYDGTKITVRNPILRYSFHPIDPSFNGYPNFDTWRTTVRNPDADKKENI
PALIAKLDLEADSTREKTYNMLKFNANWEAFSNHGEFDDTHANSLEAVHD
DIHGFVGRGAIRGHMTHALFAAFDPIFWLHHSNVDRHLSLWQALYPGVWV
TQGPEREGSMGFAPGTELNKDSALEPFYETEDKPWTSVPLTDTALLNYSY
PDFDKVKGGTPDLVRDYINDHIDRRYGIKKSEGGKNPALDLLSDFKGVTH
DHNEDLKMFDWTIQASWKKFELDDSFAIIFYFAADGSTNVTKENYIGSIN
IFRGTTPTNNLVQEGFVHLDRFIARDLDTFDPQAVHRYLKEKKLSYKVVA
DDHSVTLKSLRIRVQGRPLHLPPGVSFPRLDKNIPIVNFDDVLDLVTG
Ligand information
Ligand IDO
InChIInChI=1S/H2O/h1H2
InChIKeyXLYOFNOQVPJJNP-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		O
CACTVS 3.341[O]
FormulaO
NameOXYGEN ATOM
ChEMBLCHEMBL1098659
DrugBankDB09145
ZINC
PDB chain5m6b Chain A Residue 603 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5m6b Heterologous expression and characterization of functional mushroom tyrosinase (AbPPO4).
Resolution3.25 Å
Binding residue
(original residue number in PDB)		H57 H82 H251
Binding residue
(residue number reindexed from 1)		H55 H80 H249
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.18.1: tyrosinase.
Gene Ontology
Molecular Function
GO:0004497 monooxygenase activity
GO:0004503 tyrosinase activity
GO:0016491 oxidoreductase activity
GO:0046872 metal ion binding
Biological Process
GO:0042438 melanin biosynthetic process

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5m6b, PDBe:5m6b, PDBj:5m6b
PDBsum5m6b
PubMed28500345
UniProtC7FF05|PPO4_AGABI Polyphenol oxidase 4 (Gene Name=PPO4)

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