Structure of PDB 5luz Chain A Binding Site BS03

Receptor Information
>5luz Chain A (length=662) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SSYTVAGRNVLRWDLSPEQIKTRTEELIVQTKQVYDAVGMLGIEEVTYEN
CLQALADVEVKYIVERTMLDFPQHVSSDKEVRAASTEADKRLSRFDIEMS
MRGDIFERIVHLQETCDLGKIKPEARRYLEKSIKMGKRNGLHLPEQVQNE
IKSMKKRMSELCIDFNKNLNEDDTFLVFSKAELGALPDFIDSLEKTDDDK
YKITLKYPHYFPVMKKCCIPETRRRMEMAFNTRCKEENTIILQQLLPLRT
KVAKLLGYSTHADFVLEMNTAKSTSRVTAFLDDLSQKLKPLGEAEREFIL
NLKKKECKDRGFEYDGKINAWDLYYYMTQTEELKYSIDQEFLKEYFPIEV
VTEGLLNTYQELLGLSFEQMTDAHVWNKSVTLYTVKDKATGEVLGQFYLD
LYPREGKYNHAACFGLQPGCLLPDGSRMMAVAALVVNFSQPGRPSLLRHD
EVRTYFHQFGHVMHQICAQTDFARFSGTNVETDFVEVPSQMLENWVWDVD
SLRRLSKHYKDGSPIADDLLEKLVASRLVNTGLLTLRQIVLSKVDQSLHT
NTSLDAASEYAKYCSEILGVAATPGTNMPATFGHLAGGYDGQYYGYLWSE
VFSMDMFYSCFKKEGIMNPEVGMKYRNLILKPGGSLDGMDMLHNFLKREP
NQKAFLMSRGLH
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5luz Chain A Residue 1001 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5luz Mechanism of Peptide Binding and Cleavage by the Human Mitochondrial Peptidase Neurolysin.
Resolution2.7 Å
Binding residue
(original residue number in PDB)		H474 H478 E503
Binding residue
(residue number reindexed from 1)		H457 H461 E486
Annotation score4
Enzymatic activity
Enzyme Commision number 3.4.24.16: neurolysin.
Gene Ontology
Molecular Function
GO:0004222 metalloendopeptidase activity
GO:0008233 peptidase activity
GO:0008237 metallopeptidase activity
GO:0042277 peptide binding
GO:0046872 metal ion binding
Biological Process
GO:0006111 regulation of gluconeogenesis
GO:0006508 proteolysis
GO:0006518 peptide metabolic process
GO:0007186 G protein-coupled receptor signaling pathway
GO:1902809 regulation of skeletal muscle fiber differentiation
Cellular Component
GO:0005576 extracellular region
GO:0005737 cytoplasm
GO:0005739 mitochondrion
GO:0005758 mitochondrial intermembrane space
GO:0005829 cytosol
GO:0005886 plasma membrane

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5luz, PDBe:5luz, PDBj:5luz
PDBsum5luz
PubMed29183787
UniProtQ9BYT8|NEUL_HUMAN Neurolysin, mitochondrial (Gene Name=NLN)

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