Structure of PDB 5lew Chain A Binding Site BS03

Receptor Information
>5lew Chain A (length=919) Species: 83332 (Mycobacterium tuberculosis H37Rv) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GSSFVHLHNHTEYSMLDGAAKITPMLAEVERLGMPAVGMTDHGNMFGASE
FYNSATKAGIKPIIGVEAYIAPGSRFDTRRILWGDPSQKADDVSGSGSYT
HLTMMAENATGLRNLFKLSSHASFEGQLSKWSRMDAELIAEHAEGIIITT
GCPSGEVQTRLRLGQDREALEAAAKWREIVGPDNYFLELMDHGLTIERRV
RDGLLEIGRALNIPPLATNDCHYVTRDAAHNHEALLCVQTGKTLSDPNRF
KFDGDGYYLKSAAEMRQIWDDEVPGACDSTLLIAERVQSYADVWTPRDRM
PVFPVPDGHDQASWLRHEVDAGLRRRFPAGPPDGYRERAAYEIDVICSKG
FPSYFLIVADLISYARSAGIRVGPGRGSAAGSLVAYALGITDIDPIPHGL
LFERFLNPERTSMPDIDIDFDDRRRGEMVRYAADKWGHDRVAQVITFGTI
KTKAALKDSARIHYGQPGFAIADRITKALPPAIMAKDIPLSGITEAAEVR
GLIETDPDVRTIYQTARGLEGLIRNAGVHACAVIMSSEPLTEAIPLWKRP
QDGAIITGWDYPACEAIGLLKMDFLGLRNLTIIGDAIDNVRANRGIDLDL
ESVPLDDKATYELLGRGDTLGVFQLDGGPMRDLLRRMQPTGFEDVVAVIA
LYRPGPMGMNAHNDYADRKNNRQAIKPIHPELEEPLREILAETYGLIVYQ
EQIMRIAQKVASYSLARADILRKAMGKKKREVLEKEFEGFSDGMQANGFS
PAAIKALWDTILPFADYAFNKSHAAGYGMVSYWTAYLKANYPAEYMAGLL
TSVGDDKDKAAVYLADCRKLGITVLPPDVNESGLNFASVGQDIRYGLGAV
RNVGANVVGSLLQTRNDKGKFTDFSDYLNKIDISACNKKVTESLIKAGAF
DSLGHARKGLFLVHSDAVD
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5lew Chain A Residue 1003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5lew High-fidelity DNA replication in Mycobacterium tuberculosis relies on a trinuclear zinc center.
Resolution2.8 Å
Binding residue
(original residue number in PDB)		D23 H48 H228
Binding residue
(residue number reindexed from 1)		D17 H42 H222
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.7.7: DNA-directed DNA polymerase.
Gene Ontology
Molecular Function
GO:0003824 catalytic activity
GO:0008408 3'-5' exonuclease activity
Biological Process
GO:0006260 DNA replication

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Molecular Function
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Biological Process
External links
PDB RCSB:5lew, PDBe:5lew, PDBj:5lew
PDBsum5lew
PubMed29021523
UniProtP9WNT7|DPO3A_MYCTU DNA polymerase III subunit alpha (Gene Name=dnaE1)

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