Structure of PDB 5l0h Chain A Binding Site BS03

Receptor Information
>5l0h Chain A (length=173) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
QPVNQPILAAAQSLHWEATKWSSKGNDIIAAAKRMALLMAEMSRLVRGGS
GTKRALIQCAKDIAKASDEVTRLAKEVAKQCTDKRIRTNLLQVCERIPTI
STQLKILSTVKATMLGRTNISDEESEQATEMLVHNAQNLMQSVKETVREA
EAASIKIRTDAGFTLRWVRKTPW
Ligand information
Ligand IDPO4
InChIInChI=1S/H3O4P/c1-5(2,3)4/h(H3,1,2,3,4)/p-3
InChIKeyNBIIXXVUZAFLBC-UHFFFAOYSA-K
SMILES
SoftwareSMILES
CACTVS 3.341[O-][P]([O-])([O-])=O
ACDLabs 10.04[O-]P([O-])([O-])=O
OpenEye OEToolkits 1.5.0[O-]P(=O)([O-])[O-]
FormulaO4 P
NamePHOSPHATE ION
ChEMBL
DrugBankDB14523
ZINC
PDB chain5l0h Chain A Residue 1204 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5l0h Differential lipid binding of vinculin isoforms promotes quasi-equivalent dimerization.
Resolution2.9 Å
Binding residue
(original residue number in PDB)		S981 S982 K983 K1129
Binding residue
(residue number reindexed from 1)		S22 S23 K24 K170
Annotation score3
Enzymatic activity
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0003779 actin binding
GO:0051015 actin filament binding
Biological Process
GO:0007155 cell adhesion

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Molecular Function
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Biological Process
External links
PDB RCSB:5l0h, PDBe:5l0h, PDBj:5l0h
PDBsum5l0h
PubMed27503891
UniProtP18206|VINC_HUMAN Vinculin (Gene Name=VCL)

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