Structure of PDB 5ku1 Chain A Binding Site BS03

Receptor Information
>5ku1 Chain A (length=398) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKPACIKALTRIFKISDQDNDGTLNDAELNFFQRICFNTPLAPQALEDVK
NVVRKHISDGVADSGLTLKGFLFLHTLFIQRGRHETTWTVLRRFGYDDDL
DLTPEYLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDLDRDCALSPDELK
DLFKVFPYIPWGPDVNNTVCTNERGWITYQGFLSQWTLTTYLDVQRCLEY
LGYLGYSILTEQESQASAVTVTRDKKIDLQKKQTQRNVFRCNVIGVKNCG
KSGVLQALLGRNLMRQKKIREDHKSYYAINTVYVYGQEKYLLLHDISESE
AEIICDVVCLVYDVSNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEV
KQEYSISPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYPHV
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5ku1 Chain A Residue 703 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5ku1 Structural insights into Parkin substrate lysine targeting from minimal Miro substrates.
Resolution2.501 Å
Binding residue
(original residue number in PDB)		D317 D319 D321 A323 E328
Binding residue
(residue number reindexed from 1)		D137 D139 D141 A143 E148
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005509 calcium ion binding
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:5ku1, PDBe:5ku1, PDBj:5ku1
PDBsum5ku1
PubMed27605430
UniProtQ8IXI2|MIRO1_HUMAN Mitochondrial Rho GTPase 1 (Gene Name=RHOT1)

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