Structure of PDB 5kty Chain A Binding Site BS03

Receptor Information
>5kty Chain A (length=397) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
MKPACIKALTRIFKISDQDNDGTLNDAELNFFQRICFNTPLAPQALEDVK
NVVRKHISDGVADSGLTLKGFLFLHTLFIETTWTVLRRFGYDDDLDLTPE
YLFPLLKIPPDCTTELNHHAYLFLQSTFDKHDLDRDCALSPDELKDLFKV
FPYIPWGPDVNNTVCTNERGWITYQGFLSQWTLTTYLDVQRCLEYLGYLG
YSILTEQESQASAVTVTRDKKIDLQKKQTQRNVFRCNVIGVKNCGKSGVL
QALLGRNLMRQKKIREDHKSYYAINTVYVYGQEKYLLLHDISESEFLTEA
EIICDVVCLVYDVSNPKSFEYCARIFKQHFMDSRIPCLIVAAKSDLHEVK
QEYSISPTDFCRKHKMPPPQAFTCNTADAPSKDIFVKLTTMAMYPHV
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5kty Chain A Residue 704 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5kty Structural insights into Parkin substrate lysine targeting from minimal Miro substrates.
Resolution2.522 Å
Binding residue
(original residue number in PDB)		D197 D199 D201 T203 E208
Binding residue
(residue number reindexed from 1)		D17 D19 D21 T23 E28
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.5.-
Gene Ontology
Molecular Function
GO:0003924 GTPase activity
GO:0005509 calcium ion binding
GO:0005525 GTP binding

View graph for
Molecular Function
External links
PDB RCSB:5kty, PDBe:5kty, PDBj:5kty
PDBsum5kty
PubMed27605430
UniProtQ8IXI2|MIRO1_HUMAN Mitochondrial Rho GTPase 1 (Gene Name=RHOT1)

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