Structure of PDB 5kse Chain A Binding Site BS03

Receptor Information
>5kse Chain A (length=341) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GIQGLAKLIADVAPSAIRENDIKSYFGRKVAIDASMSIYQFLIAVRQGGD
VLQNEEGETTSHLMGMFYRTIRMMENGIKPVYVFDGKPPQLKSGELAKAS
ERRAEAEKQLQQAQAAGAEQEVEKFTKRLVKVTKQHNDECKHLLSLMGIP
YLDAPSEAEASCAALVKAGKVYAAATEDMDCLTFGSPVLMRHLTASEAKK
LPIQEFHLSRILQELGLNQEQFVDLCILLGSDYCESIRGIGPKRAVDLIQ
KHKSIEEIVRRLDPNKYPVPENWLHKEAHQLFLEPEVLDPESVELKWSEP
NEEELIKFMCGEKQFSEERIRSGVKRLSKSRQGSTLEVLFQ
Ligand information
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5kse Phosphate steering by Flap Endonuclease 1 promotes 5'-flap specificity and incision to prevent genome instability.
Resolution2.105 Å
Binding residue
(original residue number in PDB)		Q48 L53 Q54 T61 K314 Q315 F316 S317
Binding residue
(residue number reindexed from 1)		Q47 L52 Q53 T60 K313 Q314 F315 S316
Enzymatic activity
Enzyme Commision number 3.1.-.-
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003824 catalytic activity
GO:0004518 nuclease activity
GO:0016788 hydrolase activity, acting on ester bonds

View graph for
Molecular Function
External links
PDB RCSB:5kse, PDBe:5kse, PDBj:5kse
PDBsum5kse
PubMed28653660
UniProtP39748|FEN1_HUMAN Flap endonuclease 1 (Gene Name=FEN1)

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