Structure of PDB 5jdh Chain A Binding Site BS03

Receptor Information

>5jdh Chain A (length=297) Species: 243232 (Methanocaldococcus jannaschii DSM 2661)

MVILGVGYFLLGLILLYYGSDWFVLGSERIARHFNVSNFVIGATVMAIGT
SLPEILTSAYASYMHAPGISIGNAIGSCICNIGLVLGLSAIISPIIVDKN
LQKNILVYLLFVIFAAVIGIDGFSWIDGVVLLILFIIYLRWTVKNGSAEI
EKNNPSVVFSLVLLIIGLIGVLVGAELFVDGAKKIALALDISDKVIGFTL
VAFGTSLPELMVSLAAAKRNLGGMVLGNVIGSNIADIGGALAVGSLFMHL
PAENVQMAVLVIMSLLLYLFAKYSKIGRWQGILFLALYIIAIASLRM

Ligand information

• Ligand ID: CA
• InChI: InChI=1S/Ca/q+2
• InChIKey: BHPQYMZQTOCNFJ-UHFFFAOYSA-N
• SMILES:
  CACTVS 3.341: [Ca++]
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Ca+2]
• Formula: Ca
• Name: CALCIUM ION
• DrugBank: DB14577
• PDB chain: 5jdh Chain A Residue 404

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5jdh Mechanism of extracellular ion exchange and binding-site occlusion in a sodium/calcium exchanger.
• Resolution: 2.203 Å
• Binding residue (original residue number in PDB): T50 S51 E54 T209 E213
• Binding residue (residue number reindexed from 1): T50 S51 E54 T205 E209
• Annotation score: 5

Gene Ontology

Molecular Function

• GO:0005262 calcium channel activity
• GO:0008273 calcium, potassium:sodium antiporter activity

Biological Process

• GO:0006874 intracellular calcium ion homeostasis
• GO:0035725 sodium ion transmembrane transport
• GO:0055085 transmembrane transport
• GO:0070588 calcium ion transmembrane transport
• GO:0071805 potassium ion transmembrane transport

Cellular Component

• GO:0005886 plasma membrane
• GO:0016020 membrane

External links

• PDB: RCSB:5jdh, PDBe:5jdh, PDBj:5jdh
• PDBsum: 5jdh
• PubMed: 27183196
• UniProt: Q57556|Y091_METJA Uncharacterized membrane protein MJ0091 (Gene Name=MJ0091)