Structure of PDB 5jbj Chain A Binding Site BS03

Receptor Information
>5jbj Chain A (length=627) Species: 9031 (Gallus gallus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
SELHGYQLEAVAPALRGRNSIVWLPTGAGKTRAAVHVCRRHLEGRRGGRV
AVLVNKVHLVQQHLEKEFHVLRDAFKVTAVSGDSSHKCFFGQLAKGSDVV
ICTAQILQNALLSGEEEARVELTDFSLLVIDECHHTQKEAVYNKIMLSYL
QKKLSGQRDLPQILGLTASPGTGGETSFEGAVEHILQICANLDTEVIASA
REQDPFGQRLKKIMAQIQEHMEMPELPQNFGTQVYEQRIVELENRAAERF
CRKTRVCALHLRRYNDALLINDTVRMMDAFQCLQQFYADKDPTERFLATT
FEENRATLQALAGDQRYNPRLSKLEEILQEHFQPPGSSRGIVFTKTRQSA
HSLLSWLQDTAGLCGQHIRAAVLTGSGHSNQAKGMTQNEQQDVITLFRYG
ELNLLFSTSVAEEGLDIPECNIVVRYGLMTNEIAMVQAQGRARAQNSMYS
VLAKANLMERAIRAVQAMPERKYRLKIVELQRNAVLSWQVKEARSSERRQ
LHDPDDVYFHCVNCNVAVCRGSDIRTVEAMHHVNINPNFRFYYTVSSGKI
HFERTFRDWEPGCRIVCSECRQEWGMEMIYRNVTLPILSIKNFVVVTPDE
KKKYKKWSTVTFPIEEFSYLEYCSSTQ
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5jbj Chain A Residue 701 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5jbj Structural Analysis of dsRNA Binding to Anti-viral Pattern Recognition Receptors LGP2 and MDA5.
Resolution3.58 Å
Binding residue
(original residue number in PDB)		C554 C557 C610 C613
Binding residue
(residue number reindexed from 1)		C511 C514 C567 C570
Annotation score1
Enzymatic activity
Enzyme Commision number 3.6.4.13: RNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003723 RNA binding
GO:0003724 RNA helicase activity
GO:0004386 helicase activity
GO:0005524 ATP binding
GO:0016787 hydrolase activity
GO:0046872 metal ion binding
Biological Process
GO:0045087 innate immune response
Cellular Component
GO:0005737 cytoplasm

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Molecular Function
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Biological Process
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Cellular Component
External links
PDB RCSB:5jbj, PDBe:5jbj, PDBj:5jbj
PDBsum5jbj
PubMed27203181
UniProtG0YYQ5

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