Structure of PDB 5h9b Chain A Binding Site BS03

Receptor Information

>5h9b Chain A (length=269) Species: 7227 (Drosophila melanogaster)

CTRFSDNYDIKEELGKGAFSIVKRCVQKSTGFEFAAKIINTKKLTARDFQ
KLEREARICRKLHHPNIVRLHDSIQEENYHYLVFDLVTGGELFEDIVARE
FYSEADASHCIQQILESVNHCHQNGVVHRDLKPENLLLASKAKGAAVKLA
DFGLAIEVQGDHQAWFGFAGTPGYLSPEVLKKEPYGKSVDIWACGVILYI
LLVGYPPFWDEDQHRLYSQIKAGAYDYPSPEWDTVTPEAKNLINQMLTVN
PNKRITAAEALKHPWICQR

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5h9b Chain A Residue 302

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5h9b The Interaction between the Drosophila EAG Potassium Channel and the Protein Kinase CaMKII Involves an Extensive Interface at the Active Site of the Kinase.
• Resolution: 2.25 Å
• Binding residue (original residue number in PDB): N141 D157
• Binding residue (residue number reindexed from 1): N135 D151
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D136 K138 N141 D157 T177
• Catalytic site (residue number reindexed from 1): D130 K132 N135 D151 T171
• Enzyme Commision number: 2.7.11.17: calcium/calmodulin-dependent protein kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:5h9b, PDBe:5h9b, PDBj:5h9b
• PDBsum: 5h9b
• PubMed: 30381148
• UniProt: Q00168|KCC2A_DROME Calcium/calmodulin-dependent protein kinase type II alpha chain (Gene Name=CaMKII)