Structure of PDB 5gz9 Chain A Binding Site BS03

Receptor Information
>5gz9 Chain A (length=280) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
CPPGYFRMGRMRQCSRWLSCEELRTEVRQLKRVGEGAVKRVFLSEWKEHK
VALSRLTRLEMKEDFLHGLQMLKSLQSEHVVTLVGYCEEDGTILTEYHPL
GSLSNLEETLQKYQDVNTWQHRLQLAMEYVSIINYLHHSPLGTRVMCDSN
DLPKTLSQYLLTSNFSIVANDLDALPLVDSGVLIKCGHRELHGDFVAPEQ
LWPYGEDTPFQDDLMPSYNEKVDIWKIPDVSSFLLGHVEGSDMVRFHLFD
IHKACKSQIPAERPTAQNVLDAYQRVFHSL
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5gz9 Chain A Residue 1003 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5gz9 3D structural analysis of protein O-mannosyl kinase, POMK, a causative gene product of dystroglycanopathy.
Resolution2.4 Å
Binding residue
(original residue number in PDB)		Q213 D226
Binding residue
(residue number reindexed from 1)		Q158 D171
Annotation score1
Enzymatic activity
Enzyme Commision number 2.7.1.183: glycoprotein-mannosyl O(6)-kinase.
Gene Ontology
Molecular Function
GO:0004672 protein kinase activity
GO:0005524 ATP binding
GO:0019200 carbohydrate kinase activity
Biological Process
GO:0006468 protein phosphorylation
GO:0006493 protein O-linked glycosylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5gz9, PDBe:5gz9, PDBj:5gz9
PDBsum5gz9
PubMed28251761
UniProtQ3TUA9|SG196_MOUSE Protein O-mannose kinase (Gene Name=Pomk)

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