Structure of PDB 5goy Chain A Binding Site BS03

Receptor Information
>5goy Chain A (length=598) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
ATLSEEEIAMAVTAWEKGLESLPPLRPQQNPVLPVAGERNVLITSALPYV
NNVPHLGNIIGCVLSADVFARYSRLRQWNTLYLCGTDEYGTATETKALEE
GLTPQEICDKYHIIHADIYRWFNISFDIFGRTTTPQQTKITQDIFQQLLK
RGFVLQDTVEQLRCEHCARFLADRFVEGVCPFCGYEEARGDQCDKCGKLI
NAVELKKPQCKVCRSCPVVQSSQHLFLDLPKLEKRLEEWLGRTLPGSDWT
PNAQFITRSWLRDGLKPRCITRDLKWGTPVPLEGFEDKVFYVWFDATIGY
LSITANYTDQWERWWKNPEQVDLYQFMAKDNVPFHSLVFPCSALGAEDNY
TLVSHLIATEYLNYEDGKFSKSRGVGVFGDMAQDTGIPADIWRFYLLYIR
PEGQDSAFSWTDLLLKNNSELLNNLGNFINRAGMFVSKFFGGYVPEMVLT
PDDQRLLAHVTLELQHYHQLLEKVRIRDALRSILTISRHGNQYIQVNEPW
KRIKGSEADRQRAGTVTGLAVNIAALLSVMLQPYMPTVSATIQAQLQLPP
PACSILLTNFLCTLPAGHQIGTVSPLFQKLENDQIESLRQRFGGGQAK
Ligand information
Ligand IDMET
InChIInChI=1S/C5H11NO2S/c1-9-3-2-4(6)5(7)8/h4H,2-3,6H2,1H3,(H,7,8)/t4-/m0/s1
InChIKeyFFEARJCKVFRZRR-BYPYZUCNSA-N
SMILES
SoftwareSMILES
CACTVS 3.341CSCC[CH](N)C(O)=O
OpenEye OEToolkits 1.5.0CSCCC(C(=O)O)N
CACTVS 3.341CSCC[C@H](N)C(O)=O
OpenEye OEToolkits 1.5.0CSCC[C@@H](C(=O)O)N
ACDLabs 10.04O=C(O)C(N)CCSC
FormulaC5 H11 N O2 S
NameMETHIONINE
ChEMBLCHEMBL42336
DrugBankDB00134
ZINCZINC000001532529
PDB chain5goy Chain A Residue 903 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5goy The crystal structure of human cytosolic methionyl-tRNA synthetase in complex with methionine
Resolution2.278 Å
Binding residue
(original residue number in PDB)		L272 D312 W518 A521 N556
Binding residue
(residue number reindexed from 1)		L47 D87 W293 A296 N331
Annotation score5
Enzymatic activity
Catalytic site (original residue number in PDB) H280 N283 C389 C392 C435 C438 K593 K596
Catalytic site (residue number reindexed from 1) H55 N58 C164 C167 C210 C213 K368 K371
Enzyme Commision number 6.1.1.10: methionine--tRNA ligase.
Gene Ontology
Molecular Function
GO:0000166 nucleotide binding
GO:0004812 aminoacyl-tRNA ligase activity
GO:0004825 methionine-tRNA ligase activity
GO:0005524 ATP binding
Biological Process
GO:0006418 tRNA aminoacylation for protein translation
GO:0006431 methionyl-tRNA aminoacylation

View graph for
Molecular Function
View graph for
Biological Process
External links
PDB RCSB:5goy, PDBe:5goy, PDBj:5goy
PDBsum5goy
PubMed
UniProtP56192|SYMC_HUMAN Methionine--tRNA ligase, cytoplasmic (Gene Name=MARS1)

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