Structure of PDB 5fy1 Chain A Binding Site BS03

Receptor Information

>5fy1 Chain A (length=442) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KDKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLG
LFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTI
AKYAQYQASSFQESLREENEKGPFKTIKFGTNIDLSDNKKWKLQLHELTK
LPAFARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSV
NINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEANV
PVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAVER
YEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQYQT
LREALVAAGKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKTYI
VHCHDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTLALSLS

Ligand information

Ligand ID

0R0

InChI

InChI=1S/C7H5NO/c8-5-6-3-1-2-4-7(6)9/h1-4,9H

InChIKey

CHZCERSEMVWNHL-UHFFFAOYSA-N

SMILES

Software	SMILES
CACTVS 3.370	Oc1ccccc1C#N
OpenEye OEToolkits 1.7.6	c1ccc(c(c1)C#N)O
ACDLabs 12.01	N#Cc1ccccc1O

Formula

C7 H5 N O

Name

2-hydroxybenzonitrile;
2-Cyanophenol

PDB chain

5fy1 Chain A Residue 2347 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

Global view

Local view

Structure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]

PDB	5fy1 Crystal Structure of Jmjc Domain of Human Histone Demethylase Uty in Complex with N08619B
Resolution	1.78 Å
Binding residue (original residue number in PDB)	M944 H976
Binding residue (residue number reindexed from 1)	M65 H97
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.

External links

PDB	RCSB:5fy1, PDBe:5fy1, PDBj:5fy1
PDBsum	5fy1
PubMed
UniProt	O14607\|UTY_HUMAN Histone demethylase UTY (Gene Name=UTY)

[Back to BioLiP]