Structure of PDB 5fxx Chain A Binding Site BS03

Receptor Information
>5fxx Chain A (length=444) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
KDKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLG
LFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTI
AKYAQYQASSFQESLREENEKRKGPFKTIKFGTNIDLSDNKKWKLQLHEL
TKLPAFARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFC
SVNINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEA
NVPVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAV
ERYEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQY
QTLREALVAAGKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKT
YIVHCHDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTLALSLS
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5fxx Chain A Residue 4002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5fxx Crystal Structure of Jmjc Domain of Human Histone Demethylase Uty in Complex with Oxaloacetate
Resolution1.99 Å
Binding residue
(original residue number in PDB)		C1278 C1281 C1305 C1308
Binding residue
(residue number reindexed from 1)		C378 C381 C405 C408
Annotation score1
Enzymatic activity
Enzyme Commision number 1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.
External links
PDB RCSB:5fxx, PDBe:5fxx, PDBj:5fxx
PDBsum5fxx
PubMed
UniProtO14607|UTY_HUMAN Histone demethylase UTY (Gene Name=UTY)

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