Structure of PDB 5fxv Chain A Binding Site BS03

Receptor Information

>5fxv Chain A (length=442) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

KDKLNPPTPSIYLENKRDAFFPPLHQFCTNPKNPVTVIRGLAGALKLDLG
LFSTKTLVEANNEHMVEVRTQLLQPADENWDPTGTKKIWRCESNRSHTTI
AKYAQYQASSFQESLREENEKGPFKTIKFGTNIDLSDNKKWKLQLHELTK
LPAFARVVSAGNLLTHVGHTILGMNTVQLYMKVPGSRTPGHQENNNFCSV
NINIGPGDCEWFVVPEDYWGVLNDFCEKNNLNFLMSSWWPNLEDLYEANV
PVYRFIQRPGDLVWINAGTVHWVQAVGWCNNIAWNVGPLTACQYKLAVER
YEWNKLKSVKSPVPMVHLSWNMARNIKVSDPKLFEMIKYCLLKILKQYQT
LREALVAAGKEVIWHGRTNDEPAHYCSICEVEVFNLLFVTNESNTQKTYI
VHCHDCARKTSKSLENFVVLEQYKMEDLIQVYDQFTLALSLS

Ligand information

Ligand ID

MN1

InChI

InChI=1S/C6H11NO2/c8-6(9)5-1-3-7-4-2-5/h5,7H,1-4H2,(H,8,9)

InChIKey

SRJOCJYGOFTFLH-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04	O=C(O)C1CCNCC1
OpenEye OEToolkits 1.5.0	C1CNCCC1C(=O)O
CACTVS 3.341	OC(=O)C1CCNCC1

Formula

C6 H11 N O2

Name

4-CARBOXYPIPERIDINE

PDB chain

5fxv Chain A Residue 2347 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5fxv Crystal Structure of Jmjc Domain of Human Histone Demethylase Uty in Complex with N05859B
Resolution	1.91 Å
Binding residue (original residue number in PDB)	K1084 T1090 H1093 N1103 W1113
Binding residue (residue number reindexed from 1)	K182 T188 H191 N201 W211
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.14.11.68: [histone H3]-trimethyl-L-lysine(27) demethylase.

External links

PDB	RCSB:5fxv, PDBe:5fxv, PDBj:5fxv
PDBsum	5fxv
PubMed
UniProt	O14607\|UTY_HUMAN Histone demethylase UTY (Gene Name=UTY)

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