Structure of PDB 5f6c Chain A Binding Site BS03

Receptor Information
>5f6c Chain A (length=512) Species: 83333 (Escherichia coli K-12) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RHMKRMLINATQQEELRVALVDGQRLYDLDIESPGHEQKKANIYKGKITR
IEPSLEAAFVDYGAERHGFLPLKEIAREYFPANYSAHGRPNIKDVLREGQ
EVIVQIDKEERGNKGAALTTFISLAGSYLVLMPNNPRAGGISRRIEGDDR
TELKEALASLELPEGMGLIVRTAGVGKSAEALQWDLSFRLKHWEAIKKAA
ESRPAPFLIHQESNVIVRAFRDYLRQDIGEILIDNPKVLELARQHIAALG
RPDFSSKIKLYTGEIPLFSHYQIESQIESAFQREVRLPSGGSIVIDSTEA
LTAIRINSARATRGGDIEETAFNTNLEAADEIARQLRLRDLGGLIVIRFI
DMTPVRHQRAVENRLREAVRQDRARIQISHISRFGLLEMSRQRLSPSLGE
SSHHVCPRCSGTGTVRDNESLSLSILRLIEEEALKENTQEVHAIVPVPIA
SYLLNEKRSAVNAIETRQDGVRCVIVPNDQMETPHYHVLRVRKGEETPTL
SYMLPKLHEEAM
Ligand information
Ligand IDZN
InChIInChI=1S/Zn/q+2
InChIKeyPTFCDOFLOPIGGS-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Zn++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Zn+2]
FormulaZn
NameZINC ION
ChEMBLCHEMBL1236970
DrugBankDB14532
ZINC
PDB chain5f6c Chain A Residue 602 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

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PDB5f6c Substrate Recognition and Autoinhibition in the Central Ribonuclease RNase E.
Resolution3.002 Å
Binding residue
(original residue number in PDB)		C404 C407
Binding residue
(residue number reindexed from 1)		C406 C409
Annotation score4
Enzymatic activity
Enzyme Commision number 3.1.26.12: ribonuclease E.
Gene Ontology
Molecular Function
GO:0003676 nucleic acid binding
GO:0003723 RNA binding
GO:0004540 RNA nuclease activity
GO:0008995 ribonuclease E activity
Biological Process
GO:0006396 RNA processing

View graph for
Molecular Function
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Biological Process
External links
PDB RCSB:5f6c, PDBe:5f6c, PDBj:5f6c
PDBsum5f6c
PubMed30270108
UniProtP21513|RNE_ECOLI Ribonuclease E (Gene Name=rne)

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