Structure of PDB 5ean Chain A Binding Site BS03

Receptor Information
>5ean Chain A (length=1051) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
GGHMEPLDELDLLLLEAVPRVELLRKKADALFPETVLSRGVDNRYLVLAV
ETSQNERGAEEKRLHVTASQDREHEVLCILRNGWSSVPVEPGDIVHLEGD
CTSEPWIIDDDFGYFILYPDMMISGTSVASSIRCLRRAVLSETFRGSDPA
TRQMLIGTILHEVFQKAISESFAPERLQELALQTLREVRHLKEMYRLNLS
QDEILCEVEEYLPSFSKWAEDFMRKGPSSEFPQMQLSLPSDGRSSPCNIE
VVKSLDIEESIWSPRFGLKGKIDVTVGVKIHRDCKMKYKVMPLELKTGKE
SNSIEHRSQVVLYTLLSQERREDPEAGWLLYLKTGQMYPVPANHLDKREL
LKLRNWLAASLLHRVSRAAPGEEARLSALPQIIEEEKTCKYCSQIGNCAL
YSRAVEEQGDDASIPEAMLSKIQEETRHLQLAHLKYFSLWCLMLTLESQS
KDNRKTHQSIWLTPASELEESGNCVGNLVRTEPVSRVCDGQYLHNFQRKN
GPMPATNLMAGDRIILSGEERKLFALSKGYVKKMNKAAVTCLLDRNLSTL
PATTVFRLDREERHGDISTPLGNLSKLMESTDPSKRLRELIIDFREPQFI
AYLSSVLPHDAKDTVANILKGLNKPQRQAMKRVLLSKDYTLIVGMPGTGK
TTTICALVRILSACGFSVLLTSYTHSAVDNILLKLAKFKVGFLRLGQSHK
VHPDIQKFTEEEICRSRSIASLAHLEELYNSHPIVATTCMGINHPIFSRK
TFDFCIVDEASQISQPVCLGPLFFSRRFVLVGDHQQLPPLVVNREARALG
MSESLFKRLERNESAVVQLTVQYRMNRKIMSLSNKLTYAGKLECGSDRVA
NAVLALPNLKDARLSLQLYADYSDSPWLAGVLEPDNPVCFLNTDKVPAPE
QVENGGVSNVTEARLIVFLTSTFIKAGCSPSDIGVIAPYRQQLRIISDLL
ARSSVGMVEVNTVDKYQGRDKSLILVSFVRSNEDGTLGELLKDWRRLNVA
LTRAKHKLILLGSVSSLKRFPPLGTLFDHLNAEQLILDLPSREHESLSHI
L
Ligand information
Ligand IDCA
InChIInChI=1S/Ca/q+2
InChIKeyBHPQYMZQTOCNFJ-UHFFFAOYSA-N
SMILES
SoftwareSMILES
CACTVS 3.341[Ca++]
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Ca+2]
FormulaCa
NameCALCIUM ION
ChEMBL
DrugBankDB14577
ZINC
PDB chain5ean Chain A Residue 1102 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
Global viewLocal viewStructure summary

[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
[Spin on] [Spin off] [Reset]
[High quality] [Low quality]
[White background] [Black background]
PDB5ean Dna2 nuclease-helicase structure, mechanism and regulation by Rpa.
Resolution2.36 Å
Binding residue
(original residue number in PDB)		H164 D278 E299 L300
Binding residue
(residue number reindexed from 1)		H161 D273 E294 L295
Annotation score1
Enzymatic activity
Enzyme Commision number 3.1.-.-
3.6.4.12: DNA helicase.
Gene Ontology
Molecular Function
GO:0003677 DNA binding
GO:0003678 DNA helicase activity
GO:0004386 helicase activity
GO:0004518 nuclease activity
GO:0004519 endonuclease activity
GO:0005515 protein binding
GO:0005524 ATP binding
GO:0016887 ATP hydrolysis activity
GO:0016890 site-specific endodeoxyribonuclease activity, specific for altered base
GO:0017108 5'-flap endonuclease activity
GO:0017116 single-stranded DNA helicase activity
GO:0043139 5'-3' DNA helicase activity
GO:0046872 metal ion binding
GO:0051539 4 iron, 4 sulfur cluster binding
Biological Process
GO:0000076 DNA replication checkpoint signaling
GO:0000723 telomere maintenance
GO:0000729 DNA double-strand break processing
GO:0006259 DNA metabolic process
GO:0006260 DNA replication
GO:0006264 mitochondrial DNA replication
GO:0006281 DNA repair
GO:0006284 base-excision repair
GO:0032508 DNA duplex unwinding
GO:0033567 DNA replication, Okazaki fragment processing
GO:0043137 DNA replication, removal of RNA primer
GO:0043504 mitochondrial DNA repair
GO:0045740 positive regulation of DNA replication
GO:0090304 nucleic acid metabolic process
GO:1902990 mitotic telomere maintenance via semi-conservative replication
Cellular Component
GO:0000781 chromosome, telomeric region
GO:0005634 nucleus
GO:0005654 nucleoplasm
GO:0005739 mitochondrion
GO:0005760 gamma DNA polymerase complex
GO:0042645 mitochondrial nucleoid

View graph for
Molecular Function
View graph for
Biological Process
View graph for
Cellular Component
External links
PDB RCSB:5ean, PDBe:5ean, PDBj:5ean
PDBsum5ean
PubMed26491943
UniProtQ6ZQJ5|DNA2_MOUSE DNA replication ATP-dependent helicase/nuclease DNA2 (Gene Name=Dna2)

[Back to BioLiP]