Structure of PDB 5do9 Chain A Binding Site BS03

Receptor Information
>5do9 Chain A (length=314) Species: 10090 (Mus musculus) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]
RRELKLLLLGTGESGKSTFIKQMRIIHGSGYSDEDKRGFTKLVYQNIFTA
MQAMIRAMDTLKIPYKYEHNKAHAQLVREVDVEKVSAFENPYVDAIKSLW
NDPGIQECYDRRREYQLSDSTKYYLNDLDRVADPSYLPTQQDVLRVRVPT
TGIIEYPFDLQSVIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYD
QVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEEKIMYS
HLVDYFPEYDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTEN
IRFVFAAVKDTILQ
Ligand information
Ligand IDMG
InChIInChI=1S/Mg/q+2
InChIKeyJLVVSXFLKOJNIY-UHFFFAOYSA-N
SMILES
SoftwareSMILES
ACDLabs 10.04
OpenEye OEToolkits 1.5.0		[Mg+2]
CACTVS 3.341[Mg++]
FormulaMg
NameMAGNESIUM ION
ChEMBL
DrugBankDB01378
ZINC
PDB chain5do9 Chain A Residue 403 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]
Receptor-Ligand Complex Structure
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PDB5do9 Structure of the Regulator of G Protein Signaling 8 (RGS8)-G alpha q Complex: MOLECULAR BASIS FOR G alpha SELECTIVITY.
Resolution2.6 Å
Binding residue
(original residue number in PDB)		S53 T186
Binding residue
(residue number reindexed from 1)		S17 T150
Annotation score1
Enzymatic activity
Catalytic site (original residue number in PDB) E49 T54 R183 D205 Q209
Catalytic site (residue number reindexed from 1) E13 T18 R147 D169 Q173
Enzyme Commision number ?
Gene Ontology
Molecular Function
GO:0001664 G protein-coupled receptor binding
GO:0003924 GTPase activity
GO:0019001 guanyl nucleotide binding
GO:0031683 G-protein beta/gamma-subunit complex binding
Biological Process
GO:0007165 signal transduction
GO:0007186 G protein-coupled receptor signaling pathway

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Molecular Function
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Biological Process
External links
PDB RCSB:5do9, PDBe:5do9, PDBj:5do9
PDBsum5do9
PubMed26755720
UniProtP21279|GNAQ_MOUSE Guanine nucleotide-binding protein G(q) subunit alpha (Gene Name=Gnaq)

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