Structure of PDB 5d9y Chain A Binding Site BS03

Receptor Information

>5d9y Chain A (length=413) Species: 9606 (Homo sapiens) [Search protein sequence] [Download receptor structure] [Download structure with residue number starting from 1] [View receptor structure]

SCRCVEQIIEKDEGPFYTHLGAGPNVAAIREIMEERFGQKGKAIRIERVI
YTGKEGKSSQGCPIAKWVVRRSSSEEKLLCLVRERAGHTCEAAVIVILIL
VWEGIPLSLADKLYSELTETLRKYGTLTNRRCALNEERTCACQGLDPETC
GASFSFGCSWSMYYNGCKFARSKIPRKFKLLGDDPKEEEKLESHLQNLST
LMAPTYKKLAPDAYNNQIEYEHRAPECRLGLKEGRPFSGVTACLDFCAHA
HRDLHNMQNGSTLVCTLTREDNREFGGKPEDEQLHVLPLYKVSDVDEFGS
VEAQEEKKRSGAIQVLSSFRRKVRMLAEPVKTCGSDEVWSDSEQSFLDPD
IGGVAVAPTHGSILIECAKRELHATTPLKNPNRNHPTRISLVFYQHKSMN
EPKHGLALWEAKM

Ligand information

Ligand ID

InChI

InChI=1S/Fe/q+3

InChIKey

VTLYFUHAOXGGBS-UHFFFAOYSA-N

SMILES

Software	SMILES
ACDLabs 10.04 CACTVS 3.341 OpenEye OEToolkits 1.5.0	[Fe+3]

Formula

Name

FE (III) ION

PDB chain

5d9y Chain A Residue 2002 [Download ligand structure] [Download structure with residue number starting from 1] [View ligand structure]

Receptor-Ligand Complex Structure

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Structure summary

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PDB	5d9y Structural insight into substrate preference for TET-mediated oxidation.
Resolution	1.971 Å
Binding residue (original residue number in PDB)	H1382 D1384 H1881
Binding residue (residue number reindexed from 1)	H251 D253 H373
Annotation score	1

Enzymatic activity

Enzyme Commision number

1.14.11.80: methylcytosine dioxygenase.

Gene Ontology

	Molecular Function
GO:0070579	5-methylcytosine dioxygenase activity

	Biological Process
GO:0141166	chromosomal 5-methylcytosine DNA demethylation pathway

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Molecular Function

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Biological Process

External links

PDB	RCSB:5d9y, PDBe:5d9y, PDBj:5d9y
PDBsum	5d9y
PubMed	26524525
UniProt	Q6N021\|TET2_HUMAN Methylcytosine dioxygenase TET2 (Gene Name=TET2)

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