Structure of PDB 5cno Chain A Binding Site BS03

Receptor Information

>5cno Chain A (length=300) Species: 9606 (Homo sapiens)

NQALLRILKETEFKKIKVLGSGAFGTVYKGLWIPEGEKVKIPVAIKELRE
ANKEILDEAYVMASVDNPHVCRLLGICLTSTVQLITQLMPFGCLLDYVRE
HKDNIGSQYLLNWCVQIAKGMNYLEDRRLVHRDLAARNVLVKTPQHVKIT
DFGLAKLLGKVPIKWMALESILHRIYTHQSDVWSYGVTVWELMTFGSKPY
DGIPASEISSILEKGERLPQPPICTIDVYMIMRKCWMIDADSRPKFRELI
IEFSKMARDPQRYLVIQGDERMHLPSPTDSNFYRALMDEEDMDDVVDADE

Ligand information

• Ligand ID: MG
• InChI: InChI=1S/Mg/q+2
• InChIKey: JLVVSXFLKOJNIY-UHFFFAOYSA-N
• SMILES:
  ACDLabs 10.04
  OpenEye OEToolkits 1.5.0: [Mg+2]
  CACTVS 3.341: [Mg++]
• Formula: Mg
• Name: MAGNESIUM ION
• DrugBank: DB01378
• PDB chain: 5cno Chain A Residue 1002

Receptor-Ligand Complex Structure

Structure summary

• PDB: 5cno Analysis of the Role of the C-Terminal Tail in the Regulation of the Epidermal Growth Factor Receptor.
• Resolution: 1.55 Å
• Binding residue (original residue number in PDB): N818 D831
• Binding residue (residue number reindexed from 1): N138 D151
• Annotation score: 1

Enzymatic activity

• Catalytic site (original residue number in PDB): D813 A815 R817 N818 D831
• Catalytic site (residue number reindexed from 1): D133 A135 R137 N138 D151
• Enzyme Commision number: 2.7.10.1: receptor protein-tyrosine kinase.

Gene Ontology

Molecular Function

• GO:0004672 protein kinase activity
• GO:0004713 protein tyrosine kinase activity
• GO:0005524 ATP binding

Biological Process

• GO:0006468 protein phosphorylation

External links

• PDB: RCSB:5cno, PDBe:5cno, PDBj:5cno
• PDBsum: 5cno
• PubMed: 26124280
• UniProt: P00533|EGFR_HUMAN Epidermal growth factor receptor (Gene Name=EGFR)